http://www.cnr.it/ontology/cnr/individuo/prodotto/ID24047
Omega-3 Fatty Acids and the Regulation of Expression of Endothelial Pro-Atherogenic and Pro-Inflammatory Genes (Articolo in rivista)
- Type
- Label
- Omega-3 Fatty Acids and the Regulation of Expression of Endothelial Pro-Atherogenic and Pro-Inflammatory Genes (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s00232-005-0783-2 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- R. De Caterina, M. Massaro (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- IFC-CNR Lecce
Università di Chieti (literal)
- Titolo
- Omega-3 Fatty Acids and the Regulation of Expression of Endothelial Pro-Atherogenic and Pro-Inflammatory Genes (literal)
- Abstract
- By partially replacing the corresponding
omega-6 analogues in membrane phospholipids,
omega-3 fatty acids have been shown to decrease the
transcriptional activation of genes -- e.g., adhesion
molecules, chemoattractants, inflammatory cytokines
-- involved in endothelial activation in response to
inflammatory and pro-atherogenic stimuli. This reg-
ulation occurs, at least in part, through a decreased
activation of the nuclear factor-jB system of tran-
scription factors, secondary to decreased generation
of intracellular hydrogen peroxide. Such regulation
by omega-3 fatty acids is likely linked to the presence
of a higher number of double bonds in the fatty acid
chain in omega-3 compared with omega-6 fatty acids.
By similar mechanisms, omega-3 fatty acids have
been recently shown to reduce gene expression of
cyclooxygenase-2, an inflammatory gene involved,
through the activation of some metalloproteinases, in
plaque angiogenesis and plaque rupture. The
quenching of gene expression of pro-inflammatory
pro-atherogenic genes by omega-3 fatty acids has
consequences on the extent of leukocyte adhesion to
vascular endothelium, early atherogenesis and later
stages of plaque development and plaque rupture,
ultimately yielding a plausible comprehensive expla-
nation for the vasculoprotective effects of these
nutrients. (literal)
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