Post-transplant proteinuria associated with everolimus: Definition of main features with proteomics (Articolo in rivista)

Type
Label
  • Post-transplant proteinuria associated with everolimus: Definition of main features with proteomics (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/prca.200780162 (literal)
Alternative label
  • Ghiggeri G. M.; Bruschi M.; Musante L.; Candiano G.; Boccardi C.; Citti L.; Rastaldi M. P.; Mangraviti S.; Rosso G.; Larti A.; Rosati A.; Urbani A.; Bertoni E.; Salvadori M. (2008)
    Post-transplant proteinuria associated with everolimus: Definition of main features with proteomics
    in Proteomics (Weinh., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ghiggeri G. M.; Bruschi M.; Musante L.; Candiano G.; Boccardi C.; Citti L.; Rastaldi M. P.; Mangraviti S.; Rosso G.; Larti A.; Rosati A.; Urbani A.; Bertoni E.; Salvadori M. (literal)
Pagina inizio
  • 1327 (literal)
Pagina fine
  • 1337 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 2 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: Proteomics, vol. 2 pp. 1327 - 1337. WILEY-INTERSCIENCE Verlag GmbH &Co.KGaA,Weinheim, 2008. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Division of Nephrology and Laboratory on Pathophysiology of Uremia, G. Gaslini Children Hospital, Genoa, Italy, Division of Nephrology and Laboratory on Pathophysiology of Uremia, G. Gaslini Children Hospital, Genoa, Italy and Renal Child Foundation, Genoa, Italy, CNR-IFC, Pisa, D'Amico Foundation, Milan, Italy, Laboratory of Central Analysis, G. Gaslini Childrens Hospital, Genoa, Italy, Renal Unit, Careggi University Hospital Firenze, Department of Biomedical Science, Università degli Studi di Chieti e Pescara, Italy, Centro Studi sull'Invecchiamento (Ce.S.I.), Fondazione Università \"G. D'Annunzio\", Chieti, Italy (literal)
Titolo
  • Post-transplant proteinuria associated with everolimus: Definition of main features with proteomics (literal)
Abstract
  • Little is known on both the composition and mechanism(s) of proteinuria associated with the use of mTOR inhibitors, in particular of Everolimus (E). We characterized urinary proteins utilizing an integrated proteomics approach (quantitative essays, 2-DE, MALDI-TOF, Western blot) in 48 renal transplant recipients who were alternatively treated with E (n = 31) or with enteric coated myco-phenolic acid (EC-MPA) (n = 17). Twelve E patients (39%) developed high (.3 g/day) or intermediate proteinuria (1-3 g) compared to four (23%) of the EC-MPA group. Urinary proteins (p,0.001), b2 microglobulin (p,0.001) and a1microglobulin (p,0.025) were higher in E than in EC-MPA, appeared more rapidly and were inversely correlated with the day of treatment. Proteomics showed a marked increase of all urinary components in E and EC-MPA patients, major changes involving typical components of glomerular damage (albumin, a1-Zn glycoprotein, a2HS glycoprotein, leucin-richa2-glycoprotein) and specific bio-markers for E (clusters of a1-antitrypsin fragments and monoclonal l chains). Finally, inter-a-trypsin-inhibitor heavy chain H4 precursor was decreased in E and EC-MPA urine compared to normal urine. In conclusion, E induced massive and generalized proteinuria of mixed glomerular and tubular origin that was correlated with the start of treatment and reached a nephrotic range in few cases. Specific urinary markers reflect renal alterations related to the transplant or specific alterationsassociated with the drug. (literal)
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