Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(e-caprolactone) blends for tissue engineering applications in the form of hollow fibres (Articolo in rivista)

Type
Label
  • Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(e-caprolactone) blends for tissue engineering applications in the form of hollow fibres (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Chiono V.; Ciardelli G.; Vozzi G.; Sotgiu M. G.; Vinci B.; Domenici C.; Giusti P. (2008)
    Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(e-caprolactone) blends for tissue engineering applications in the form of hollow fibres
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Chiono V.; Ciardelli G.; Vozzi G.; Sotgiu M. G.; Vinci B.; Domenici C.; Giusti P. (literal)
Pagina inizio
  • 938 (literal)
Pagina fine
  • 953 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 85 A (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: Journal of Biomedical Materials Research Part A, vol. 85 A (4) pp. 938 - 953. Wiley Periodicals, Inc, 2008. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • , CNR-IFC, Pisa (literal)
Titolo
  • Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(e-caprolactone) blends for tissue engineering applications in the form of hollow fibres (literal)
Abstract
  • In this work, hollow fibers to be used as guides for tissue engineering applications were produced by dry-jet-wet spinning of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(e-caprolactone) (PHBHV/PCL) solutions in chloroform with various weight ratios between the components (PHBHV/PCL 100/0; 80/20; 60/40; 50/50; 40/60; 20/80; 0/100 w/w). Fibers obtained from PHBHV/PCL blends had a low degree of surface and bulk porosity, depending on composition. Physico-chemical characterisation involving scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) showed that PHBHV/PCL blends are compatible. Interactions between blend components were studied by Fourier transform infrared total reflectance spectroscopy (FTIR-ATR), DSC analysis and polarised optical microscopy analysis. Homogeneity of blend composition was assessed by IR-Chemical Imaging analysis. PHBHV/PCL samples were found to be weakly hydrophilic and their biocompatibility was proved by in vitro tests using mouse fibroblasts. Mechanical properties of PHBHV/PCL blends were investigated by stress-strain tests, showing an increasing ductility of blend samples with increasing the PCL amount. Hollow fibres supported fibroblasts attachment and proliferation depending on composition and porosity degree. (literal)
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