http://www.cnr.it/ontology/cnr/individuo/prodotto/ID23986
Chitosan/gelatin blends for biomedical applications (Articolo in rivista)
- Type
- Label
- Chitosan/gelatin blends for biomedical applications (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/jbm.a.31492 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Ettore Pulieri; Valeria Chiono; Gianluca Ciardelli; Giovanni Vozzi; Arti Ahluwalia;
Claudio Domenici; Federico Vozzi; Paolo Giusti (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- In: Journal of Biomedical Materials Research Part A, vol. 86 (2) pp. 311 - 322. Wiley Periodicals, Inc, 2008. (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Centro ''E. Piaggio'', University of Pisa, Pisa;
Department of Chemical Engineering, Industrial Chemistry and Materials Science,
University of Pisa, Pisa;
Politecnico in Turin, Department of Mechanics, Turin;
C.N.R. Institute for Composite and Biomedical Materials, Pisa;
C.N.R. Institute of Clinical Physiology, Pisa (literal)
- Titolo
- Chitosan/gelatin blends for biomedical applications (literal)
- Abstract
- Blends between chitosan (CS) and gelatin (G)with various compositions (CS/G 0/100 20/80, 40/60, 60/40, 100/0 w/w) were produced as candidate materials for biomedical applications. Dehydro-thermal crosslinking was adopted to promote the formation of amide and ester bonds between the macromolecules ((CS/G)-t). The effect of composition and crosslinking on the physico-chemical properties of the samples was evaluated by scanning electron microscopy, thermogravimetry, contact angle measurements, dissolution and swelling tests. Mechanical properties of (CS/G)-t samples were also determined through stress-strain and creep-recovery tests. The elastic moduli of dry blend samples showed a positive deviation from the additive law of the in-series model, because of interactions and/or chemical bonds between components. The comparison between the elastic moduli of wet samples and those of different human tissues showed that (CS/G)-t substrates can be suitable for soft-tissue reconstruction. (CS/G)-t two-dimensional scaffolds were fabricated by micro-molding, based on the use of a polydimethylsiloxane mould to create patterns with microscale resolution on cast films. Biocompatibility of (CS/G)-t samples was studied by means of cell tests using NIH-3T3 fibroblasts. Finally, the evaluation of the affinity of (CS/G)-t samples towards neuroblastoma cells adhesion and proliferation was performed, showing promising results for the blend containing 80 wt % gelatin. (literal)
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