CSF phosporylated TAU protein levels correlate with cerebral glucose metabolism assessed with PET in Alzheimer's disease (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• CSF phosporylated TAU protein levels correlate with cerebral glucose metabolism assessed with PET in Alzheimer's disease (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Ceravolo R.; Borghetti D.; Kiferle L.; Tognoni G.; Giorgetti A.; Neglia D.; Sassi N.; Frosini D.; Rossi C.; Petrozzi L.; Siciliano G.; Murri L. (2008)
  CSF phosporylated TAU protein levels correlate with cerebral glucose metabolism assessed with PET in Alzheimer's disease
  in Brain research bulletin
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ceravolo R.; Borghetti D.; Kiferle L.; Tognoni G.; Giorgetti A.; Neglia D.; Sassi N.; Frosini D.; Rossi C.; Petrozzi L.; Siciliano G.; Murri L. (literal)

Pagina inizio

• 80 (literal)

Pagina fine

• 84 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 76 (literal)

Rivista

• Brain research bulletin (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: Brain Research Bulletin, vol. 76 pp. 80 - 84. Elsevier, 2008. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Università di Pisa, IFC-CNR - Fondazione G. Monasterio Pisa, IFC-CNR - Fondazione G. Monasterio Pisa (literal)

Titolo

• CSF phosporylated TAU protein levels correlate with cerebral glucose metabolism assessed with PET in Alzheimer's disease (literal)

Abstract

• One major goal of drug development would be the establishment of biomarkers as objective indicators of normal biological and pathogenetic processes, or pharmacological response to a therapeutic intervention. A potential approach is to investigate proteins in CSF linked to key neuropathological features of Alzheimer's disease (AD). Recently CSF phosphorylated-Tau (p-Tau) levels have been reported to reflect neurofibrillary changes within the brain of patients with AD, however the use of serial CSF investigations in order to monitor the disease progression is not applicable. PET with FDG reveals characteristic patterns in AD patients, however so far no correlation between in vivo metabolic information and pathological features has been reported. In the present study, we tested whether CSF Tau levels correlate with metabolic rate for glucose consumption in a cohort of 28 AD patients. We found a statistically significative correlation between both CSF total and p-TAU protein and relative metabolic indexes obtained from 18FDG-PET scans in parietal, temporal and occipital lobes bilaterally. These results indicate the existence of a correlation between impairment of cerebral metabolism, estimated throughout FDG-PET, and CSF Tau protein levels. (literal)

Prodotto di

• FISIOPATOLOGIA CARDIOPOLMONARE E METABOLICA (ME.P01.011.001) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• DANILO NEGLIA (Persona)
• Assuero Giorgetti (Persona)

Insieme di parole chiave

• Parole chiave di "CSF phosporylated TAU protein levels correlate with cerebral glucose metabolism assessed with PET in Alzheimer's disease" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• FISIOPATOLOGIA CARDIOPOLMONARE E METABOLICA (ME.P01.011.001) (Modulo)

Autore CNR di

• DANILO NEGLIA (Persona)
• Assuero Giorgetti (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Brain research bulletin (Rivista)

Insieme di parole chiave di

• Parole chiave di "CSF phosporylated TAU protein levels correlate with cerebral glucose metabolism assessed with PET in Alzheimer's disease" (Insieme di parole chiave)