http://www.cnr.it/ontology/cnr/individuo/prodotto/ID23943

Blood glutathione as independent marker of lipid peroxidation in heart failure (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Blood glutathione as independent marker of lipid peroxidation in heart failure (Articolo in rivista) (literal)

Anno

2007-01-01T00:00:00+01:00 (literal)

Alternative label

Campolo J.; De Maria R.; Caruso R.; Accinni R.; Turazza F.; Parolini M.; Roubina E.; De Chiara B.; Cighetti G.; Frigerio M.; Vitali E.; Parodi O. (2007)
Blood glutathione as independent marker of lipid peroxidation in heart failure
in International journal of cardiology (print)
(literal)

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Campolo J.; De Maria R.; Caruso R.; Accinni R.; Turazza F.; Parolini M.; Roubina E.; De Chiara B.; Cighetti G.; Frigerio M.; Vitali E.; Parodi O. (literal)

Pagina inizio

45 (literal)

Pagina fine

50 (literal)

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117 (literal)

Rivista

International journal of cardiology (Rivista)

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In: International Journal of Cardiology, vol. 117 pp. 45 - 50. Elsevier, 2007. (literal)

Note

ISI Web of Science (WOS) (literal)

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CNR Clinical Physiology Institute -- Milan, Niguarda Ca' Granda Hospital, Milan, Italy Cardiology Department, Niguarda Ca' Granda Hospital Milan, Italy Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Italy (literal)

Titolo

Blood glutathione as independent marker of lipid peroxidation in heart failure (literal)

Abstract

Background: Aminothiols have a critical function as intracellular redox buffers and constitute furthermore an important extracellular redox system. Lipid peroxidation is increased in chronic heart failure (CHF), but the contribution of each thiol to oxidative stress in this syndrome has not been evaluated. Aim: To assess the correlation between blood and plasma concentrations of aminothiols and lipid peroxidation as marker of oxidative stress in CHF patients. Methods: Blood reduced glutathione (GSH), plasma total and reduced cysteine, cysteinylglycine, homocysteine, GSH, ?-tocopherol,ascorbic acid, and free malondialdehyde (MDA) were assessed in samples obtained from 26 CHF heart transplant candidates and 26 age- and gender-matched controls with atherosclerotic risk factors and no history of cardiovascular disease. Results are expressed as median and interquartile range (I-III). Results: MDA levels were significantly higher in CHF patients than in controls [1.03 (0.56-1.60) ?M vs. 0.70 (0.40-0.83) ?M, p=0.006]. Blood reduced GSH concentrations were significantly higher [662 (327-867) ?M vs. 416 (248-571) ?M, p=0.016], while ?-tocopherol levels were significantly lower [15 (13-19) ?M vs. 21 (17-32) ?M, p=0.001] in CHF patients than in controls. By multivariate logistic regression analysis, the only independent predictors of lipid peroxidation, as expressed by MDA levels ?1.00 ?M, were increased blood GSH concentrations (OR 1.003 per unit, 95% CI 1.001 to 1.006, p=0.008), ischemic (OR 20, 95% CI 2.6 to 155, p=0.004) and non ischemic CHF etiology (OR 11, 95% CI 1.3 to 99, p=0.026). Conclusions: Abnormalities in intracellular GSH cycling are associated to increased lipid peroxidation in CHF. (literal)

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