Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1093/eurheartj/ehm225 (literal)

Alternative label

• Andreassi M. G.; Cioppa A.; Manfredi S.; Palmieri C.; Botto N.; Picano E. (2007)
  Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures
  in European heart journal
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Andreassi M. G.; Cioppa A.; Manfredi S.; Palmieri C.; Botto N.; Picano E. (literal)

Pagina inizio

• 2195 (literal)

Pagina fine

• 2199 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 28 (literal)

Rivista

• European heart journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: European Heart Journal, vol. 28 (18) pp. 2195 - 2199. Oxford Journals, 2007. (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR Institute of Clinical Physiology, G. Pasquinucci Hospital, Via Aurelia Sud-Montepepe, 54100 Massa, Italy and Department of Invasive Cardiology, Montevergine Clinic, Mercogliano, Italy (literal)

Titolo

• Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures (literal)

Abstract

• Aims We evaluated whether radiation exposure during interventional cardiovascular procedures can induce damage to deoxyribonucleic acid (DNA). Methods and results Micronucleus assay (MN) was performed as biomarker of chromosomal damage and intermediate endpoint in carcinogenesis. Seventy-two patients (54 males, age = 63.8 +/- 10.5 years) undergoing a wide range of radiation exposure during invasive cardiovascular procedures (coronary angiography, n = 9; percutaneous coronary intervention, n = 9; peripheral transluminal angioplasty, n = 37; and cardiac resynchronization therapy, n = 17) were enrolled. MN frequency was evaluated before, 2, and 24 h after the radiation exposure. Dose-area product (DAP; Gy cm(2)) was assessed as physical measure of radiation load. DAP value was 96.0 +/- 63.9 Gy cm(2). MN frequency was 15.1 +/- 7.1 per thousand at baseline and showed a significant rise at 2 h (17.5 +/- 6.5 per thousand, P = 0.03) and 24 h (18.5 +/- 7.3 per thousand, P = 0.004) after procedures. Conclusion Our results corroborate the current radioprotection assumption that even modest radiation load can damage the DNA of the cell and induce chromosome alterations which are early predictors of increased cancer risk. (literal)

Prodotto di

• Echolab (ME.P01.007.001) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)
• Tassonomia clinica molecolare - Tassonomia clinica molecolare (ME.P05.003.001) (Modulo)

Autore CNR

• EUGENIO PICANO (Persona)
• MARIAGRAZIA ANDREASSI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIAGRAZIA ANDREASSI (Unità di personale interno)
• EUGENIO PICANO (Persona)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• Echolab (ME.P01.007.001) (Modulo)
• Tassonomia clinica molecolare - Tassonomia clinica molecolare (ME.P05.003.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European heart journal (Rivista)

Insieme di parole chiave di

• Keywords of "Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures" (Insieme di parole chiave)