pH-activated doxorubicin release from polyelectrolyte complex layer coated mesoporous silica nanoparticles (Articolo in rivista)

Type
Label
  • pH-activated doxorubicin release from polyelectrolyte complex layer coated mesoporous silica nanoparticles (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.micromeso.2013.06.016 (literal)
Alternative label
  • L. Minati1,V. Antonini2, M. Dalla Serra2, G. Speranza3,1, F. Enrichi 4,1, P. Riello5 (2013)
    pH-activated doxorubicin release from polyelectrolyte complex layer coated mesoporous silica nanoparticles
    in Microporous and mesoporous materials (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • L. Minati1,V. Antonini2, M. Dalla Serra2, G. Speranza3,1, F. Enrichi 4,1, P. Riello5 (literal)
Pagina inizio
  • 86 (literal)
Pagina fine
  • 91 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://dx.doi.org/10.1016/j.micromeso.2013.06.016 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 180 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1IFN - CNR, Institute of Photonics & Nanotechnology, CSMFO Lab., Via alla Cascata 56/C Povo, 38123 Trento, Italy 2Istituto di Biofisica, Consiglio Nazionale delle Ricerche & Fondazione Bruno Kessler, via alla Cascata 56/C, 38123 Trento, Italy 3 Fondazione Bruno Kessler, Via Sommarive 18, Povo 38123 Trento, Italy 4CIVEN (Coordinamento Interuniversitario Veneto per le Nanotecnologie), via delle Industrie 5, 30175, Marghera (VE), Italy 5Dipartimento di Chimica Fisica, Università Ca' Foscari di Venezia e INSTM, via Torino 155/b, 30170, Mestre (VE), Italy (literal)
Titolo
  • pH-activated doxorubicin release from polyelectrolyte complex layer coated mesoporous silica nanoparticles (literal)
Abstract
  • Mesoporous silica nanoparticles (MSN) functionalized with doxorubicin (Dox) and coated with a polyelectrolyte complex layer were tested in vitro to investigate drug release in cellular environment. The mesoporous silica nanoparticles inner surface was efficiently functionalized with the positively charged antitumoral drug doxorubicin. Polyelectrolyte layer complex was adsorbed on the outer surface of the MSN improving colloidal stability in biological media and forming an electrostatic barrier against the doxorubicin diffusion at biological pH. Dox-loaded silica nanoparticles showed a pH-dependent drug release behavior. Cell uptake of mesoporous silica nanoparticles and drug release dynamic were real-time monitored by laser scanning confocal microscopy. These results suggest that MSN could be exploited as smart carrier with pH-triggered drug releasing properties. (literal)
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