Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects (Articolo in rivista)

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  • Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1053/j.gastro.2007.04.068 (literal)
Alternative label
  • Gastaldelli A.; Cusi K.; Pettiti M.; Hardies J.; Miyazaki Y.; Berria R.; Buzzigoli E.; Sironi A. M.; Cersosimo E.; Ferrannini E.; Defronzo R. A. (2007)
    Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects
    in Gastroenterology (N.Y.N.Y., 1943); WB Saunders Co.-Elsevier Inc., Philadelphia (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gastaldelli A.; Cusi K.; Pettiti M.; Hardies J.; Miyazaki Y.; Berria R.; Buzzigoli E.; Sironi A. M.; Cersosimo E.; Ferrannini E.; Defronzo R. A. (literal)
Pagina inizio
  • 496 (literal)
Pagina fine
  • 506 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/17681171 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 133 (literal)
Rivista
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  • In: Gastroenterology, vol. 133 pp. 496 - 506. Gastroenterology, 2007. (literal)
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  • 2 (literal)
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  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • *Division of Diabetes, the Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas; ?Institute of Clinical Physiology, National Research Council, Pisa, Italy; §Obstetrics-Gynecology Department, Case Western Reserve University, Cleveland, Ohio; and the Department ofInternal Medicine, University of Pisa, Pisa, Italy (literal)
Titolo
  • Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects (literal)
Abstract
  • BACKGROUND AND AIMS: Abdominal fat accumulation (visceral/hepatic) has been associated with hepatic insulin resistance (IR) in obesity and type 2 diabetes (T2DM). We examined the relationship between visceral/hepatic fat accumulation and hepatic IR/accelerated gluconeogenesis (GNG). METHODS: In 14 normal glucose tolerant (NGT) (body mass index [BMI] = 25 +/- 1 kg/m(2)) and 43 T2DM (24 nonobese, BMI = 26 +/- 1; 19 obese, BMI = 32 +/- 1 kg/m(2)) subjects, we measured endogenous (hepatic) glucose production (3-(3)H-glucose) and GNG ((2)H(2)O) in the basal state and during 240 pmol/m(2)/min euglycemic-hyperinsulinemic clamp, and liver (LF) subcutaneous (SAT)/visceral (VAT) fat content by magnetic resonance spectroscopy/magnetic resonance imaging. RESULTS: LF was increased in lean T2DM compared with lean NGT (18% +/- 3% vs 9% +/- 2%, P .03), but was similar in lean T2DM and obese T2DM (18% +/- 3% vs 22% +/- 3%; P (literal)
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