http://www.cnr.it/ontology/cnr/individuo/prodotto/ID23915

Quantification of Liver Glucose Metabolism by Positron Emission Tomography: Validation Study in Pigs (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Quantification of Liver Glucose Metabolism by Positron Emission Tomography: Validation Study in Pigs (Articolo in rivista) (literal)

Anno

2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1053/j.gastro.2006.12.040 (literal)

Alternative label

Iozzo P.; Jarvisalo M.; Kiss J.; Borra R.; Naum G.; Viljanen A.; Viljanen T.; Gastaldelli A.; Buzzigoli E.; Guiducci L.; Barsotti E.; Savunen T.; Knuuti J.; Haaparanta-Solina M.; Ferrannini E.; Nuutila P. (2007)
Quantification of Liver Glucose Metabolism by Positron Emission Tomography: Validation Study in Pigs
in Gastroenterology (N.Y.N.Y., 1943); WB Saunders Co.-Elsevier Inc., Philadelphia (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Iozzo P.; Jarvisalo M.; Kiss J.; Borra R.; Naum G.; Viljanen A.; Viljanen T.; Gastaldelli A.; Buzzigoli E.; Guiducci L.; Barsotti E.; Savunen T.; Knuuti J.; Haaparanta-Solina M.; Ferrannini E.; Nuutila P. (literal)

Pagina inizio

531 (literal)

Pagina fine

542 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.sciencedirect.com/science/article/pii/S0016508506026904 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

132 (literal)

Rivista

Gastroenterology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

In: Gastroenterology, vol. 132 pp. 531 - 542. Gastroenterology, 2007. (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

*Turku PET Centre and Departments of ¶Surgery and #Medicine, University of Turku, Turku, Finland; and PET Centre, Institute of Clinical Physiology, CNR National Research Council, §SSSUP-Medical Sciences Branch, and ?Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy (literal)

Titolo

Quantification of Liver Glucose Metabolism by Positron Emission Tomography: Validation Study in Pigs (literal)

Abstract

BACKGROUND & AIMS: The liver is inaccessible to organ balance measurements in humans. To validate [(;18)F]fluorodeoxyglucose ([(18)F]FDG) positron emission tomography (PET) in the quantification of hepatic glucose uptake (HGU), we determined [(18)F]FDG modeling parameters, lumped constant (LC), and input functions (single arterial versus dual). METHODS: Anesthetized pigs were studied during fasting (n = 6), physiologic (n = 4), and supraphysiologic (n = 4) hyperinsulinemia. PET was performed with C(15)O (blood pool) and [(18)F]FDG (glucose uptake). 6,6-Deuterated glucose ([(2)H]G) was coinjected with [(18)F]FDG and blood collected from the carotid artery and portal and hepatic veins to compute LC as ratio between tracers fractional extraction. HGU was estimated from PET images and ex vivo from high-performance liquid chromatography measurements of liver [(18)F]FDG versus [(18)F]FDG-6-phosphate and [(18)F]-glycogen. Endogenous glucose production was measured with [(2)H]G and hepatic blood flow by flowmeters. RESULTS: HGU was increased in hyperinsulinemia versus fasting (P .05). Fractional extraction of [(18)F]FDG and [(2)H]G was similar (not significant), intercorrelated (r 0.95, P .0001), with a modest underestimation of HGU by the former. CONCLUSIONS: [(18)F]FDG-PET-derived parameters provide accurate quantification of HGU and estimates of liver perfusion and glucose production. In the liver, LC of [(18)F]FDG is nearly unitary. Using a single arterial input introduces only a small error in estimation of HGU. (literal)

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