Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells (Articolo in rivista)

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Label
  • Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1160/TH06-07-0402 (literal)
Alternative label
  • Del Turco S.; Basta G.; Lazzerini G.; Evangelisti M.; Rainaldi G.; Tanganelli P.; Camera M.; Tremoli E.; De Caterina R. (2007)
    Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells
    in Thrombosis and haemostasis
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Del Turco S.; Basta G.; Lazzerini G.; Evangelisti M.; Rainaldi G.; Tanganelli P.; Camera M.; Tremoli E.; De Caterina R. (literal)
Pagina inizio
  • 210 (literal)
Pagina fine
  • 219 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 98 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: Thrombosis and Haemostasis, vol. 98 pp. 210 - 219. doi:10.1160/TH06-07-0402. Schattauer, 2007. (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • C.N.R. Institute of Clinical Physiology, Pisa; Institute of Pathology, the University of Siena;Institute of Pharmacological Sciences, University of Milan; \"G. d'Annunzio\" University, Chieti; (literal)
Titolo
  • Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells (literal)
Abstract
  • Tissue factor (TF) is expressed on the endothelium in response to inflammatory mediators, giving endothelial cells a pro-thrombotic phenotype. Since fish-derived n-3 fatty acids (FA) have been associated with reduced incidence of myocardial infarction, we investigated the endothelial effects of the most abundant n-3 FA, docosahexaenoate (DHA), on TF expression. Human umbilical vein endothelial cells were pre-incubated with DHA (or stearate and arachidonate as controls) for 48-72 hours, and then stimulated with bacterial lipopolysaccharide(LPS) or tumor necrosis factor-?. Pre-incubation of endothelial cells with DHA (but not stearate or arachidonate) concentration-dependently reduced surface protein exposure, independent of TF mRNA or total protein expression regulation. Conversely, DHA treatment in conjunction with activating stimuli,induced the release of endothelial TF-exposing microparticles from endothelial cells,quantitatively accounting for the decreased TF cell surface exposure. In conclusion,DHA treatment,with a time-course consistent with its incorporation in membrane phospholipids, increases the release of TF-exposing microparticles from endothelial cells, accounting for decreased endothelial cell TF surface exposure, thus potentially modifying the overall endothelial control of microparticle-related effects. (literal)
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