http://www.cnr.it/ontology/cnr/individuo/prodotto/ID23894

Low plasma glutathione levels after reperfused acute myocardial infarction are associated with late cardiac events (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Low plasma glutathione levels after reperfused acute myocardial infarction are associated with late cardiac events (Articolo in rivista) (literal)

Anno

2007-01-01T00:00:00+01:00 (literal)

Alternative label

De Chiara B.; Mafrici A.; Campolo J.; Famoso G.; Sedda V.; Parolini M.; Cighetti G.; Lualdi A.; Fiorentini C.; Parodi O. (2007)
Low plasma glutathione levels after reperfused acute myocardial infarction are associated with late cardiac events
in Coronary artery disease
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

De Chiara B.; Mafrici A.; Campolo J.; Famoso G.; Sedda V.; Parolini M.; Cighetti G.; Lualdi A.; Fiorentini C.; Parodi O. (literal)

Pagina inizio

77 (literal)

Pagina fine

82 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

18 (literal)

Rivista

Coronary artery disease (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

In: Coronary Artery Disease, vol. 18 pp. 77 - 82. Lippincott Williams & Wilkins, 2007. (literal)

Note

ISI Web of Science (WOS) (literal)

Titolo

Low plasma glutathione levels after reperfused acute myocardial infarction are associated with late cardiac events (literal)

Abstract

Objective: To clarify whether an altered redox state persists in the subacute phase of myocardial infarction and if specific redox patterns are associated with later cardiac events.Methods Ninety-seven patients [80 men, median 63 (interquartile range, 53, 69) years] with a first acute myocardial infarction, with (53%) or without ST segment elevation, treated with successful percutaneous interventions, were tested at 5-6 days after admission for plasma a-tocopherol, ascorbic acid, total and reduced homocysteine, cysteine, glutathione, cysteinylglycine and blood-reduced glutathione, all assessed by high-pressure liquid chromatography. Free malondialdehyde was evaluated by gas chromatography. A subgroup of 14 patients had adjunctive blood samples within 1 h and at 72 h after angioplasty. Blood samples from 44 patients matched for age, sex, and risk factors served as controls. Patients were followed up for median 15 (interquartile range, 9, 17) months for cardiac events.Results All plasma-reduced aminothiols, vitamins and plasma total glutathione were significantly lower in myocardial infarction at 5-6 days than in controls. In the 14 myocardial infarction patients sampled repeatedly, plasma-reduced glutathione, cysteinylglycine, total glutathione, and a-tocopherol significantly decreased,whereas blood-reduced glutathione, total homocysteine,and cysteine significantly increased over time. During follow-up, 20 of 97 (21%) patients had adverse cardiac events. Multivariate analysis revealed that only plasmareduced glutathione was independently associated with events (hazard ratio 0.42, 95% confidence interval 0.18-0.99, P=0.04).Conclusions Acute myocardial infarction patients have an altered redox state at 5-6 days after successful reperfusion with respect to controls. Low plasma levels of reduced glutathione at discharge are associated with cardiac events at follow-up. (literal)

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