Heat shock protein 70-1 gene expression in pediatric heart surgery using blood cardioplegia (Articolo in rivista)

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  • Heat shock protein 70-1 gene expression in pediatric heart surgery using blood cardioplegia (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Vittorini S.; Storti S.; Andreani G.; Giusti L.; Murzi B.; Furfori P.; Baroni A.; De Lucia V.; Luisi V. S.; Clerico A. (2007)
    Heat shock protein 70-1 gene expression in pediatric heart surgery using blood cardioplegia
    in Clinical chemistry and laboratory medicine
    (literal)
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  • Vittorini S.; Storti S.; Andreani G.; Giusti L.; Murzi B.; Furfori P.; Baroni A.; De Lucia V.; Luisi V. S.; Clerico A. (literal)
Pagina inizio
  • 244 (literal)
Pagina fine
  • 248 (literal)
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  • 45 (literal)
Rivista
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  • In: Clinical Chemistry and Laboratory Medicine, vol. 45 (2) pp. 244 - 248. Walter de Gruyter, 2007. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Heat shock protein 70-1 gene expression in pediatric heart surgery using blood cardioplegia (literal)
Abstract
  • Background: In response to many stress stimuli, cardiomyocytes produce a common set of heat shock proteins (HSP). Up-regulation of HSP70-1 (the inducible isoform) is known to reduce the risk of myocardial cell damage during open-heart surgery and seems to be protective against ischemia. We assessed hsp70-1 gene expression during blood cardioplegic arrest in children undergoing surgical correction of congenital heart defects. Methods: In tissue samples taken from the right atrium of 59 pediatric patients, we examined hsp70-1 gene expression using a real-time quantitative reverse transcription PCR, with 18S rRNA as internal standard. Results: On average, hsp70-1 gene expression was higher than the baseline level by a factor of 1.44±0.17 (mean±SEM). A significant relationship between hsp70-1 mRNA levels and aortic cross-clamp time was observed (R2=0.069, p=0.044). Conversely, no significant correlation was observed between hsp70- 1 mRNA levels and temperature. Conclusions: These data suggest that blood cardioplegia can induce an increment in the expression of hsp70-1, confirming its protective role in ischemia/ reperfusion injury (literal)
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