Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1152/ajpendo.00624.2006 (literal)

Alternative label

• Cusi K.; Kashyap S.; Gastaldelli A.; Bajaj M.; Cersosimo E. (2007)
  Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes
  in American journal of physiology: endocrinology and metabolism; American Physiological Society, Bethesda (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cusi K.; Kashyap S.; Gastaldelli A.; Bajaj M.; Cersosimo E. (literal)

Pagina inizio

• E1775 (literal)

Pagina fine

• E1781 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/17299078 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 292 (literal)

Rivista

• American journal of physiology: endocrinology and metabolism (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: American Journal of Physiology-Endocrinology and Metabolism, vol. 292 pp. E1775 - E1781. American Journal of Physiology-Endocrinology and Metabolism, 2007. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Univ Texas, Hlth Sci Ctr, Diabet Div, Dept Med, San Antonio, TX 78284 USA 2. Univ Texas, Hlth Sci Ctr, Audie L Murphy Vet Adm Med Ctr, San Antonio, TX 78284 USA (literal)

Titolo

• Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes (literal)

Abstract

• Elevated plasma FFA cause beta-cell lipotoxicity and impair insulin secretion in nondiabetic subjects predisposed to type 2 diabetes mellitus [T2DM; i.e., with a strong family history of T2DM (FH+)] but not in nondiabetic subjects without a family history of T2DM. To determine whether lowering plasma FFA with acipimox, an antilipolytic nicotinic acid derivative, may enhance insulin secretion, nine FH+ volunteers were admitted twice and received in random order either acipimox or placebo (double-blind) for 48 h. Plasma glucose/insulin/C-peptide concentrations were measured from 0800 to 2400. On day 3, insulin secretion rates (ISRs) were assessed during a +125 mg/dl hyperglycemic clamp. Acipimox reduced 48-h plasma FFA by 36% (P 0.001) and increased the plasma C-peptide relative to the plasma glucose concentration or DeltaC-peptide/Deltaglucose AUC (+177%, P (literal)

Editore

• American Physiological Society (Editore)

Prodotto di

• Tassonomia clinica molecolare - Tassonomia clinica molecolare (ME.P05.003.001) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• AMALIA GASTALDELLI (Persona)

Insieme di parole chiave

• Keywords of "Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• AMALIA GASTALDELLI (Persona)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• Tassonomia clinica molecolare - Tassonomia clinica molecolare (ME.P05.003.001) (Modulo)

Editore di

• American Physiological Society (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• American journal of physiology: endocrinology and metabolism (Rivista)

Insieme di parole chiave di

• Keywords of "Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes" (Insieme di parole chiave)