Evaluation of the efficacy of oral deferiprone in beta-thalassemia major by multislice multiecho T2* (Articolo in rivista)

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Label
  • Evaluation of the efficacy of oral deferiprone in beta-thalassemia major by multislice multiecho T2* (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pepe A.; Lombardi M.; Positano V.; Cracolici E.; Capra M.; Malizia R.; Prossomariti L.; De Marchi D.; Midiri M.; Maggio A. (2006)
    Evaluation of the efficacy of oral deferiprone in beta-thalassemia major by multislice multiecho T2*
    in European journal of haematology
    (literal)
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  • Pepe A.; Lombardi M.; Positano V.; Cracolici E.; Capra M.; Malizia R.; Prossomariti L.; De Marchi D.; Midiri M.; Maggio A. (literal)
Pagina inizio
  • 183 (literal)
Pagina fine
  • 192 (literal)
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  • 76 (literal)
Rivista
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  • In: European Journal of Haematology, vol. 76 (3) pp. 183-192. Blackwell, 2006. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Evaluation of the efficacy of oral deferiprone in beta-thalassemia major by multislice multiecho T2* (literal)
Abstract
  • Objectives: Oral deferiprone (L1) appears to be promising in the treatment of beta-thalassemia major (TM) patients. T2* magnetic resonance imaging (MRI) with a single measurement in the mid-ventricular septum was validated as a quantitative evaluation of myocardial iron overload. Previous studies suggested a marked heterogeneity of iron distribution in the myocardium. We set up a multislice multiecho T2* MRI for the detection of this heterogeneity. The aim of our study was to investigate differences between the L1 vs. the subcutaneous desferrioxamine (DF)-treated patients using this new approach. Methods: Thirty-six beta-TM patients (age 29 ± 8 yr) underwent MRI. Eighteen patients received long-term L1, and 18 other patients matched for age and sex received DF. T2* multiecho sequences on three short axis views of the left ventricle were obtained and analyzed by custom-made software. In each slice, the myocardium was automatically segmented into four segments. Cine-dynamic images were also obtained to evaluate biventricular function. Results: For multislice T2* technique, the coefficient of variation for intra- and inter-observer, and inter-study reproducibility was 3.9%, 4.7%, and 5.5%, respectively. The global heart T2* value was significantly higher in the L1 vs. DF group (35 ± 7 vs. 27 ± 2 ms; P = 0.02). The number of segments with normal T2* value (20 ms) was significantly higher in the L1 vs. the DF group (11 ± 1 vs. 8 ± 5 segments; P = 0.03). We did not detect significant differences in biventricular function parameters. Conclusions: This new approach confirms that L1 could be more effective than DF in removal of myocardial iron. (literal)
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