Radioimmunoassays for plasma C-type natriuretic peptide determination: a methodological evaluation (Articolo in rivista)

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Label
  • Radioimmunoassays for plasma C-type natriuretic peptide determination: a methodological evaluation (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1515/CCLM.2005.110 (literal)
Alternative label
  • Del Ry S.; Maltinti M.; Emdin M.; Passino C.; Catapano G.; Giannessi D. (2005)
    Radioimmunoassays for plasma C-type natriuretic peptide determination: a methodological evaluation
    in Clinical chemistry and laboratory medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Del Ry S.; Maltinti M.; Emdin M.; Passino C.; Catapano G.; Giannessi D. (literal)
Pagina inizio
  • 641 (literal)
Pagina fine
  • 645 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://ukpmc.ac.uk/abstract/MED/16006261/reload=0;jsessionid=MITlM1gZV3S1eZukQM0v.0 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 43 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: \"Clin Chem Lab Med\"43,2005,6,641-645 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR Institute of Clinical Physiology, Pisa, Italy (literal)
Titolo
  • Radioimmunoassays for plasma C-type natriuretic peptide determination: a methodological evaluation (literal)
Abstract
  • C-Type natriuretic peptide (CNP) is a member of the family of natriuretic peptides with vasodilatory properties, and is produced and secreted by endothelial cells. It seems to play a central role in the paracrine vasomotor control of tone and to be important in several clinical conditions characterized by endothelial dysfunction. We evaluated the analytical performance of a commercially available radioimmunoassay for CNP after a preliminary extraction with Sep-Pak C18. Its analytical reliability was checked by determination of CNP plasma levels in healthy subjects (n = 23) and in patients with different diseases, likely characterized by endothelial dysfunction, such as chronic heart failure (n = 133) and cirrhosis (n = 84). The extraction yield was 78+/-3%. Accuracy of the radiommunological determination was evaluated by dilution (45-370 microL of extracted plasma) and recovery tests (>80%). Between- and within-assay variabilities were < or = 10% and analytical sensitivity was 0.41+/-0.015 pg/tube. Plasma CNP in patients with chronic heart failure and with cirrhosis was significantly raised compared to controls (p<0.0001 and p = 0.001, respectively). The sensitivity, accuracy and variability levels of the method proposed for CNP assay was suitable for reliable detection of changes in CNP plasma levels in the clinical setting. (literal)
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