The effect of chronic ethanol intake on brain NGF level and on NGF-target tissues of adult mice. (Articolo in rivista)

Type
Label
  • The effect of chronic ethanol intake on brain NGF level and on NGF-target tissues of adult mice. (Articolo in rivista) (literal)
Anno
  • 1993-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/0376-8716(93)90068-2 (literal)
Alternative label
  • Aloe L (1), Bracci-Laudiero L (1), Tirassa P (1) (1993)
    The effect of chronic ethanol intake on brain NGF level and on NGF-target tissues of adult mice.
    in Drug and Alcohol Dependence
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Aloe L (1), Bracci-Laudiero L (1), Tirassa P (1) (literal)
Pagina inizio
  • 159 (literal)
Pagina fine
  • 167 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 31 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • (1) Institute of Neurobiology, CNR, Rome, Italy. (literal)
Titolo
  • The effect of chronic ethanol intake on brain NGF level and on NGF-target tissues of adult mice. (literal)
Abstract
  • The effect of ethanol consumption on the forebrain and hypothalamus of adult mice was investigated. A consistent decrease of biological activity and of nerve growth factor (NGF) immunoreactivity was observed in the hippocampus and hypothalamus of alcohol-treated mice. Biochemical studies also indicate that chronic ethanol intake causes a reduction in the level of choline-acetyltransferase in the septum, hippocampus and striatum, but not in the cortex and other brain regions. This study provides evidence that long-term ethanol intake causes impairment of brain NGF level and of the cholinergic enzyme, regulated by NGF, suggesting that NGF synthesis and/or biological activity is affected in alcohol-related brain neuropathology. (literal)
Autore CNR

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