http://www.cnr.it/ontology/cnr/individuo/prodotto/ID23701

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: site and mechanisms (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: site and mechanisms (Articolo in rivista) (literal)

Anno

2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1007/s00125-005-1682-x (literal)

Alternative label

Bugianesi E.; Gastaldelli A.; Vanni E.; Gambino R.; Cassader M.; Baldi S.; Ponti V.; Pagano G.; Ferrannini E.; Rizzetto M. (2005)
Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: site and mechanisms
in Diabetologia (Berl.); SPRINGER, 233 SPRING ST, NEW YORK, NY 10013 (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Bugianesi E.; Gastaldelli A.; Vanni E.; Gambino R.; Cassader M.; Baldi S.; Ponti V.; Pagano G.; Ferrannini E.; Rizzetto M. (literal)

Pagina inizio

634 (literal)

Pagina fine

642 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.ncbi.nlm.nih.gov/pubmed/15747110 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

48,4 (literal)

Rivista

Diabetologia (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

In: \"Diabetologia \"48,2005,4 634-642 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

4 (literal)

Note

PubMe (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Univ Turin, Azienda Osped San Giovanni Battista, UOADU Gastroepatol, I-10126 Turin, Italy 2. Univ Turin, San Giovanni Battista Hosp, Div Gastrohepatol, Turin, Italy 3. CNR, Inst Clin Physiol, Metab Unit, I-56100 Pisa, Italy 4. Univ Pisa, Dept Internal Med, Pisa, Italy 5. Univ Turin, San Giovanni Battista Hosp, Dept Internal Med, Turin, Italy (literal)

Titolo

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: site and mechanisms (literal)

Abstract

Aims/Hypothesis: Non-alcoholic fatty liver disease (NAFLD) has been associated with the metabolic syndrome. However, it is not clear whether insulin resistance is an independent feature of NAFLD, and it remains to be determined which of the in vivo actions of insulin are impaired in this condition. Methods: We performed a twostep (1.5 and 6 pmol min(-1) kg(-1)) euglycaemic insulin clamp coupled with tracer infusion ([6,6-H-2(2)] glucose and [H-2(5)] glycerol) and indirect calorimetry in 12 non-obese, normolipidaemic, normotensive, non-diabetic patients with biopsy-proven NAFLD and six control subjects. Results: In NAFLD patients, endogenous glucose production ( basal and during the clamp) was normal; however, peripheral glucose disposal was markedly decreased ( by 30% and 45% at the low and high insulin doses, respectively, p< 0.0001) at higher plasma insulin levels (p = 0.05), due to impaired glucose oxidation (p = 0.003) and glycogen synthesis ( p< 0.001). Compared with control subjects, glycerol appearance and lipid oxidation were significantly increased in NAFLD patients in the basal state, and were suppressed by insulin to a lesser extent ( p< 0.05 - 0.001). The lag phase of the in vitro copper-catalysed peroxidation of LDL particles was significantly shorter in the patients than in the control subjects ( 48 +/- 12 vs 63 +/- 13 min, p< 0.04). Lipid oxidation was significantly related to endogenous glucose production, glucose disposal, the degree of hepatic steatosis, and LDL oxidisability. Conclusions/interpretation: Insulin resistance appears to be an intrinsic defect in NAFLD, with the metabolic pattern observed indicating that adipose tissue is an important site. (literal)

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