http://www.cnr.it/ontology/cnr/individuo/prodotto/ID236834
Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. (Articolo in rivista)
- Type
- Label
- Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. (Articolo in rivista) (literal)
- Anno
- 1995-01-01T00:00:00+01:00 (literal)
- Alternative label
Lambiase A (1,2), Bonini S (1), Bonini S (3), Micera A (2), Magrini L (3), Bracci-Laudiero L (2), Aloe L (2). (1995)
Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells.
in Investigative ophthalmology & visual science
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Lambiase A (1,2), Bonini S (1), Bonini S (3), Micera A (2), Magrini L (3), Bracci-Laudiero L (2), Aloe L (2). (literal)
- Pagina inizio
- Pagina fine
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- Rivista
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- Note
- ISI Web of Science (WOS) (literal)
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- (1)Department of Ophthalmology, University of Rome Tor Vergata, Rome, Italy
(2) Institute of Neurobiology, CNR, Rome, Italy
(3) Chair of Clinical Immunology and Allergology, Second University of Naples, Naples, Italy (literal)
- Titolo
- Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. (literal)
- Abstract
- PURPOSE: To evaluate the nerve growth factor (NGF) plasma concentration in
patients with vernal keratoconjunctivitis and to correlate it with the
histopathology and immunopathology of the disease.
METHODS: An immunoenzymatic assay was performed to measure NGF plasma levels in
patients with vernal keratoconjunctivitis and in healthy matched controls. A
competitive radioimmunoassay was used to detect eosinophil cationic protein (ECP)
and total specific immunoglobulin E (IgE) serum levels. Histologic evaluation was
performed in tarsal and bulbar conjunctival biopsies.
RESULTS: Plasma levels of NGF were significantly higher (P < 0.001) in patients
with vernal keratoconjunctivitis (mean = 8224.47 +/- 7802.53 pg/ml; median = 121
pg/ml) than in controls (mean = 51.68 +/- 5.94 pg/ml; median 42.5 pg/ml).
Conjunctival tissue showed a significant increase of mast cells, eosinophils, and
lymphocytes in vernal keratoconjunctivitis. A significant correlation was
observed between plasma levels of NGF and the number of mast cells in the tarsal
conjunctiva (Cc = 0.81; P < 0.005) and bulbar conjunctiva (Cc = 0.77; P < 0.01)
of patients with vernal keratoconjunctivitis. No correlation was found between
NGF plasma levels and total IgE serum levels in patients with vernal
keratoconjunctivitis; NGF plasma levels were inversely related to the number of
circulating eosinophils (Cc = -0.61; P < 0.05) and to the increased serum levels
of ECP (Cc = -0.71; P < 0.02).
CONCLUSIONS: These data represent the first reported evidence of increased NGF
plasma levels in an allergic human disease and suggest a possible relationship
between this neurotrophic polypeptide and inflammatory cells in vernal
keratoconjunctivitis. (literal)
- Autore CNR
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