http://www.cnr.it/ontology/cnr/individuo/prodotto/ID236162
NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF? (Articolo in rivista)
- Type
- Label
- NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF? (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/S0165-5728(01)00475-1 (literal)
- Alternative label
Bracci-Laudiero L (1,2) Aloe L (2), Buanne P (2), Finn A (1), Stenfors C (1), Vigneti E (3) ,
Theodorsson E (4) , Lundeberg T (1). (2002)
NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF?
in Journal of neuroimmunology (Print); Elsevier, New York (Stati Uniti d'America)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bracci-Laudiero L (1,2) Aloe L (2), Buanne P (2), Finn A (1), Stenfors C (1), Vigneti E (3) ,
Theodorsson E (4) , Lundeberg T (1). (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1) Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
2) Institute of Neurobiology, CNR, Rome, Italy
3) Institute of cell Biology, CNR, Rome, Italy
4) Division of Clinical Chemistry, Faculty of Health Sciences, Linkoping, Sweden (literal)
- Titolo
- NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF? (literal)
- Abstract
- We investigated whether the sensory neuropeptide, calcitonin gene-related peptide
(CGRP), could be synthesised by human lymphocytes. Our results indicate that in
activated B-cells, there is a strong expression of CGRP gene transcripts, which
is almost absent in resting cells. Since B-cells autocrinally produce NGF, the
neutralisation of endogenous NGF by anti-NGF antibodies resulted in a marked
reduction in CGRP expression in both resting and activated B-cells. Thus, NGF
appears to directly affect the synthesis of CGRP in B-cells as in sensory
neurons. By regulating CGRP synthesis in lymphocytes and neuronal cells, NGF can
influence the intensity and duration of the immune response. (literal)
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