NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF? (Articolo in rivista)

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  • NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF? (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/S0165-5728(01)00475-1 (literal)
Alternative label
  • Bracci-Laudiero L (1,2) Aloe L (2), Buanne P (2), Finn A (1), Stenfors C (1), Vigneti E (3) , Theodorsson E (4) , Lundeberg T (1). (2002)
    NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF?
    in Journal of neuroimmunology (Print); Elsevier, New York (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bracci-Laudiero L (1,2) Aloe L (2), Buanne P (2), Finn A (1), Stenfors C (1), Vigneti E (3) , Theodorsson E (4) , Lundeberg T (1). (literal)
Pagina inizio
  • 58 (literal)
Pagina fine
  • 65 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 123 (literal)
Rivista
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  • 8 (literal)
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  • 1-2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1) Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden 2) Institute of Neurobiology, CNR, Rome, Italy 3) Institute of cell Biology, CNR, Rome, Italy 4) Division of Clinical Chemistry, Faculty of Health Sciences, Linkoping, Sweden (literal)
Titolo
  • NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF? (literal)
Abstract
  • We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, the neutralisation of endogenous NGF by anti-NGF antibodies resulted in a marked reduction in CGRP expression in both resting and activated B-cells. Thus, NGF appears to directly affect the synthesis of CGRP in B-cells as in sensory neurons. By regulating CGRP synthesis in lymphocytes and neuronal cells, NGF can influence the intensity and duration of the immune response. (literal)
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