Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Alternative label

• Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M. (2000)
  Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma
  in Cancer research (Chic. Ill., Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M. (literal)

Pagina inizio

• 1546 (literal)

Pagina fine

• 1551 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 60 (literal)

Rivista

• Cancer research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Centro Medicina Nucleare, Consiglio Nazionale delle Ricerche, Naples, Italy Dipartimento di Scienze Biomorfologiche e Funzionali, Università Federico II, Naples, Italy (literal)

Titolo

• Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (literal)

Abstract

• The regulatory mechanisms underlying the overexpression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in highly invasive breast carcinomas remain poorly understood. In this study, we have simultaneously determined the level of uPAR and the activity of the transcription factor Sp1 in 14 breast carcinomas and 5 benign lesions. We found that uPAR levels and Sp1-binding activity are coordinately elevated in malignant tumors (r, 0.94; P < 0.001). On the contrary, undetectable or only barely detectable levels of uPAR and Sp1 activity were found in benign breast lesions. Finally, the engagement of uPAR by catalytically inactive uPA in the MDA-MB-231 breast carcinoma cell line results in a rapid up-regulation of Sp1-binding activity followed by an increase of uPAR protein. These results, taken together, suggest the existence of a uPA-dependent positive regulatory loop that may progressively enhance malignant breast cell invasiveness. (literal)

Prodotto di

• Sviluppo di Approcci Diagnostici e Terapeutici Innovativi in Oncologia (ME.P03.001.004) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• MARCO SALVATORE (Persona)
• ANTONELLA ZANNETTI (Unità di personale interno)
• SILVANA DEL VECCHIO (Persona)
• ROSA FONTI (Unità di personale interno)

Incoming links:

Autore CNR di

• SILVANA DEL VECCHIO (Persona)
• MARCO SALVATORE (Persona)
• ROSA FONTI (Unità di personale interno)
• ANTONELLA ZANNETTI (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Sviluppo di Approcci Diagnostici e Terapeutici Innovativi in Oncologia (ME.P03.001.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cancer research (Rivista)