Monogenic mouse models of social dysfunction: Implications for autism (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Monogenic mouse models of social dysfunction: Implications for autism (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bbr.2013.01.002 (literal)

Alternative label

• Oddi D.a, b; Crusio W.E.c, d; D'Amato F.R.a,b; Pietropaolo S.c, d (2013)
  Monogenic mouse models of social dysfunction: Implications for autism
  in Behavioural brain research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Oddi D.a, b; Crusio W.E.c, d; D'Amato F.R.a,b; Pietropaolo S.c, d (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• 2013 Jan 14 [Epub ahead of print] (literal)

Rivista

• Behavioural brain research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a CNR, Cell Biology and Neurobiology Institute, Rome, Italy. b IRCCS, Santa Lucia Foundation, Rome, Italy. c Univ. Bordeaux, INCIA, UMR 5287, 33400 Talence, France. d CNRS, INCIA, UMR 5287, 33400 Talence, France. (literal)

Titolo

• Monogenic mouse models of social dysfunction: Implications for autism (literal)

Abstract

• Autism is a pervasive disorder characterized by a complex symptomatology, based principally on social dysfunction. The disorder has a highly complex, largely genetic etiology, involving an impressive variety of genes, the precise contributions of which still remain to be determined. For this reason, a reductionist approach to the study of autism has been proposed, employing monogenic animal models of social dysfunction, either by targeting a candidate gene, or by mimicking a single-gene disorder characterized by autistic symptoms. In the present review, we discuss this monogenic approach by comparing examples of each strategy: the mu opioid receptor knock-out (KO) mouse line, which targets the opioid system (known to be involved in the control of social behaviors); and the Fmr1-KO mouse, a model for Fragile X syndrome (a neurodevelopmental syndrome that includes autistic symptoms). The autistic-relevant behavioral phenotypes of the mu-opioid and Fmr1-KO mouse lines are described here, summarizing previous work by our research group and others, but also providing novel experimental evidence. Relevant factors influencing the validity of the two models, such as sex differences and age at testing, are also addressed, permitting an extensive evaluation of the advantages and limits of monogenic mouse models for autism. (literal)

Prodotto di

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Autore CNR

• DIEGO ODDI (Unità di personale esterno)
• FRANCESCA ROMANA D'AMATO (Persona)

Insieme di parole chiave

• Parole chiave di "Monogenic mouse models of social dysfunction: Implications for autism" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FRANCESCA ROMANA D'AMATO (Persona)
• DIEGO ODDI (Unità di personale esterno)

Prodotto

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Behavioural brain research (Rivista)

Insieme di parole chiave di

• Parole chiave di "Monogenic mouse models of social dysfunction: Implications for autism" (Insieme di parole chiave)