Identical T-cell receptor beta chain rearrangements are present in T cells infiltrating the jejunal mucosa of untreated celiac patients. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Identical T-cell receptor beta chain rearrangements are present in T cells infiltrating the jejunal mucosa of untreated celiac patients. (Articolo in rivista) (literal)

Anno

• 1997-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0198-8859(97)00071-2 (literal)

Alternative label

• Prisco A, Troncone R, Mazzarella G, Gianfrani C, Auricchio S, Even J, Tiberio C, Guardiola J, De Berardinis P. (1997)
  Identical T-cell receptor beta chain rearrangements are present in T cells infiltrating the jejunal mucosa of untreated celiac patients.
  in Human immunology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Prisco A, Troncone R, Mazzarella G, Gianfrani C, Auricchio S, Even J, Tiberio C, Guardiola J, De Berardinis P. (literal)

Pagina inizio

• 22 (literal)

Pagina fine

• 33 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 55 (literal)

Rivista

• Human immunology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• Scopus (literal)
• MedLine (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• International Institute of Genetics and Biophysics, C.N.R., Napoli (A.P., J.G.) Italy, Department of Pediatrics, University Federico II, Napoli (R.T., G.M., C.G., S.A.) Italy, Institute of Protein Biochemistry and Enzymology, C.N.R., Napoli, Italy (C.T., P.D.B.); Institut Pasteur, Paris, France (J.E.). (literal)

Titolo

• Identical T-cell receptor beta chain rearrangements are present in T cells infiltrating the jejunal mucosa of untreated celiac patients. (literal)

Abstract

• he intestinal mucosal lesion in celiac disease is characterized by a predominant T-cell infiltration of both epithelium and lamina propria. However, a restricted use of T-cell receptors (TCR) in T lymphocytes infiltrating the jejunal mucosa of celiac patients has not been reported. Based on an immunohistochemical survey of jejunal biopsies from a cohort of untreated celiac patients, we demonstrated a small but significant increase of V?8.1/2+ T cells in the lamina propria, but not in the epithelium nor in the peripheral blood. Sequence analysis indicated the existence of a variable degree of clonality of V?8+ T cells in the celiac mucosa. More importantly, the recurrence of identical CDR3 regions in some patients was also observed. The altered distribution of V?8+ T cells and the presence of identical CDR3 regions in celiac patients, but not in controls was independently confirmed by CDR3 size analysis in a further cohort of patients. These findings suggest that disease-specific variations of the TCRBV8 repertoire are present in the small intestinal mucosa of untreated celiac patients. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• PIERGIUSEPPE DE BERARDINIS (Unità di personale interno)
• ANTONELLA PRISCO (Persona)
• JOHN GUARDIOLA (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR di

• PIERGIUSEPPE DE BERARDINIS (Unità di personale interno)
• JOHN GUARDIOLA (Persona)
• ANTONELLA PRISCO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Human immunology (Rivista)