Mesenchymal stromal cells primed with Paclitaxel attract and kill leukaemia cells, inhibit angiogenesis and improve survival of leukaemia-bearing mice (Articolo in rivista)

Type
Label
  • Mesenchymal stromal cells primed with Paclitaxel attract and kill leukaemia cells, inhibit angiogenesis and improve survival of leukaemia-bearing mice (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/bjh.12196 (literal)
Alternative label
  • Pessina Augusto1; Cocce Valentina1; Pascucci Luisa2; Bonomi Arianna1,3; Cavicchini Loredana1; Sisto Francesca1; Maura Ferrari4; Emilio Ciusani5; Antonio Crovace6; Falchetti Maria Laura7; Zicari Sonia8; Caruso Arnaldo8; Navone Stefania3; Marfia Giovanni3; Benetti Anna9; Ceccarelli Piero2; Parati Eugenio3; Alessandri Giulio3 (2013)
    Mesenchymal stromal cells primed with Paclitaxel attract and kill leukaemia cells, inhibit angiogenesis and improve survival of leukaemia-bearing mice
    in British journal of haematology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pessina Augusto1; Cocce Valentina1; Pascucci Luisa2; Bonomi Arianna1,3; Cavicchini Loredana1; Sisto Francesca1; Maura Ferrari4; Emilio Ciusani5; Antonio Crovace6; Falchetti Maria Laura7; Zicari Sonia8; Caruso Arnaldo8; Navone Stefania3; Marfia Giovanni3; Benetti Anna9; Ceccarelli Piero2; Parati Eugenio3; Alessandri Giulio3 (literal)
Pagina inizio
  • 766 (literal)
Pagina fine
  • 778 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Epub 2013 Jan 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 160 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Department of Biomedical, Surgical and Dental Sciences, University of Milan, 2 Section of Veterinary Anatomy, Department of Biopathological Sciences and Hygiene of Animal and Food Productions, University of Perugia, 3 Cellular Neurobiology Laboratory, Department of Cerebrovascular Diseases, Fondazione IRCCS Neurological Institute Carlo Besta, Milan, 4 Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, 5 Laboratory of Clinical Pathology and Neurogenetic Medicine, Fondazione IRCCS Neurological Institute Carlo Besta, Milan, 6Dipartimento dell'Emergenza e dei Trapianti di Organi (D.E.T.O.), Sezione di Chirurgia Veterinaria, Universit√† degli Studi di Bari AldoMoro, Bari, 7 Institute of Neurobiology and Molecular Medicine, CNR, Rome (*) 8 Department of Microbiology, University of Brescia and Spedali Civili 9 2nd Department of Pathology, University of Brescia and Spedali Civili, Brescia, Italy (*) L'INMM √® confluito nell'IBCN con provvedimento n. 116 prot. n. 91899 del 21/12/2010. (literal)
Titolo
  • Mesenchymal stromal cells primed with Paclitaxel attract and kill leukaemia cells, inhibit angiogenesis and improve survival of leukaemia-bearing mice (literal)
Abstract
  • Current leukaemia therapy focuses on increasing chemotherapy efficacy. Mesenchymal stromal cells (MSCs) have been proposed for carrying and delivery drugs to improve killing of cancer cells. We have shown that MSCs loaded with Paclitaxel (PTX) acquire a potent anti-tumour activity. We investigated the effect of human MSCs (hMSCs) and mouse SR4987 loaded with PTX (hMSCsPTX and SR4987PTX) on MOLT-4 and L1210, two leukaemia cell (LCs) lines of human and mouse origin, respectively. SR4987PTX and hMSCsPTX showed strong anti-LC activity. hMSCsPTX, co-injected with MOLT-4 cells or intra-tumour injected into established subcutaneous MOLT-4 nodules, strongly inhibited growth and angiogenesis. In BDF1-mice-bearing L1210, the intraperitoneal administration of SR4987PTX doubled mouse survival time. In vitro, both hMSCs and hMSCsPTX released chemotactic factors, bound and formed rosettes with LCs. In ultrastructural analysis of rosettes, hMSCsPTX showed no morphological alterations while the attached LCs were apoptotic and necrotic. hMSCs and hMSCsPTX released molecules that reduced LC adhesion to microvascular endothelium (hMECs) and down-modulated ICAM1 and VCAM1 on hMECs. Priming hMSCs with PTX is a simple procedure that does not require any genetic cell manipulation. Once the effectiveness of hMSCsPTX on established cancers in mice is proven, this procedure could be proposed for leukaemia therapy in humans. (literal)
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