Functional imaging of multidrug resistance in breast cancer (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Functional imaging of multidrug resistance in breast cancer (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Vecchio SD, Zannetti A, Salvatore B, Paone G, Fonti R, Salvatore M. (2006)
  Functional imaging of multidrug resistance in breast cancer
  in Physica medica (Testo stamp.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vecchio SD, Zannetti A, Salvatore B, Paone G, Fonti R, Salvatore M. (literal)

Pagina inizio

• 24 (literal)

Pagina fine

• 27 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 1 (literal)

Rivista

• Physica medica (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Biostructures and Biomages of the National Research Council (CNR), Naples (Italy); Institute of Biostructures and Biomages of the National Research Council (CNR), Naples (Italy). (literal)

Titolo

• Functional imaging of multidrug resistance in breast cancer (literal)

Abstract

• Intrinsic or acquired multidrug resistance is the major cause of treatment failure in many human cancers. Multiple cellular mechanisms may contribute to the development of multidrug resistance including overexpression of P-glycoprotein (Pgp). The use of 99mTc-labeled lipophilic cations, which are transport substrate of Pgp, raised the possibility to predict the tumor response to treatment and to identify patients who will become refractory to subsequent therapy. Among these agents, 99mTc-MIBI is the most widely evaluated tracer and may serve as a paradigm of this class of compounds. In particular, many studies have shown the prognostic value of 99mTc-MIBI scan in different types of malignancy including breast cancer and the correlation with the expression of Pgp. However, additional mechanisms of cell resistance, mainly involving alterations of apoptosis, may also affect 99mTc-MIBI uptake in tumors. In particular, overexpression of the anti-apoptotic protein Bcl-2 prevents tumor cells to enter apoptosis and inhibits tracer accumulation into mitochondria. Therefore, while an absent or reduced early tracer uptake in large breast carcinomas reflects the existence of a defective apoptotic program, an enhanced tracer clearance in 99mTc-MIBI positive lesions reflects the activity of drug transporters such as Pgp. The existence of two different mechanisms underlying the predictive role of 99mTc-MIBI scan may be important to establish whether individual patients may benefit from Pgp inhibitors or Bcl-2 antagonists. (literal)

Prodotto di

• Sviluppo di Approcci Diagnostici e Terapeutici Innovativi in Oncologia (ME.P03.001.004) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• ANTONELLA ZANNETTI (Unità di personale interno)
• MARCO SALVATORE (Persona)
• BARBARA SALVATORE (Unità di personale interno)
• ROSA FONTI (Unità di personale interno)

Incoming links:

Autore CNR di

• MARCO SALVATORE (Persona)
• ROSA FONTI (Unità di personale interno)
• ANTONELLA ZANNETTI (Unità di personale interno)
• BARBARA SALVATORE (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Sviluppo di Approcci Diagnostici e Terapeutici Innovativi in Oncologia (ME.P03.001.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Physica medica (Rivista)