Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation. (Articolo in rivista)

Type
Label
  • Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation. (Articolo in rivista) (literal)
Anno
  • 1999-01-01T00:00:00+01:00 (literal)
Alternative label
  • Mondelli MU, Cerino A, Lisa A, Brambilla S, Segagni L, Cividini A, Bissolati M, Missale G, Bellati G, Meola A, Bruniercole B, Nicosia A, Galfre' G, Silini E. (1999)
    Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation.
    in Hepatology (Baltim. Md.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mondelli MU, Cerino A, Lisa A, Brambilla S, Segagni L, Cividini A, Bissolati M, Missale G, Bellati G, Meola A, Bruniercole B, Nicosia A, Galfre' G, Silini E. (literal)
Pagina inizio
  • 537 (literal)
Pagina fine
  • 545 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://onlinelibrary.wiley.com/store/10.1002/hep.510300233/asset/510300233_ftp.pdf?v=1&t=hi7jw81a&s=d4196d39309806e32b9739a922b675eb729647e9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 30 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Laboratori di Ricerca-Area Infettivologica, Istituto di Clinica delle Malattie Infettive and the Dipartimento di Patologia Umana ed Ereditaria, University of Pavia and IRCCS Policlinico San Matteo, Pavia, Italy; the IGM-CNRì, Pavia, Italy; the Laboratorio di Immunopatologia Virale, Azienda Ospedaliera di Parma; the Divisione di Medicina Generale ed Epatologia ''Crespi'', Ospedale Niguarda-Ca' Granda, Milano, Italy; the Istituto di Ricerche di Biologia Molecolare \"P. Angeletti\", Pomezia, Italy. (literal)
Titolo
  • Antibody responses to hepatitis C virus hypervariable region 1: evidence for cross-reactivity and immune-mediated sequence variation. (literal)
Abstract
  • Sequence heterogeneity of hepatitis C virus (HCV) is unevenly distributed along the genome, and maximal variation is confined to a short sequence of the HCV second envelope glycoprotein (E2), designated hypervariable region 1 (HVR1), whose biological function is still undefined. We prospectively studied serological responses to synthetic oligopeptides derived from HVR1 sequences of patients with acute and chronic HCV infection obtained at baseline and after a defined follow-up period. Extensive serological cross-reactivity for unrelated HVR1 peptides was observed in the majority of the patients. Antibody response was restricted to the IgG1 isotype and was focused on the carboxyterminal end of the HVR1 region. Cross-reactive antibodies could be readily elicited following immunization of mice with multiple antigenic peptides carrying HVR1 sequences derived from our patients. The vigor and heterogeneity of cross-reactive antibody responses were significantly higher in patients with chronic hepatitis compared with those with acute hepatitis and in patients infected with HCV type 2 compared with patients infected with other viral genotypes (predominantly type 1), which suggest that higher time-related HVR1 sequence diversification previously described for type 2 may result from immune selection. The finding of a statistically significant correlation between HVR1 sequence variation, and intensity, and cross-reactivity of humoral immune responses provided stronger evidence in support of the contention that HCV variant selection is driven by the host's immune pressure. (literal)
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