HSV-1 AND CNS: THE LONG TERM EFFECTS OF A LASTING AFFAIR (Articolo in rivista)

Type
Label
  • HSV-1 AND CNS: THE LONG TERM EFFECTS OF A LASTING AFFAIR (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • G. DE CHIARA 1, M.E. MARCOCCI 2, L. CIVITELLI 2, R. PIACENTINI 3, C. RIPOLI 3, E. GARACI 4, C. GRASSI 3, A.T. PALAMARA 5,6 (2012)
    HSV-1 AND CNS: THE LONG TERM EFFECTS OF A LASTING AFFAIR
    in European Journal of Neurodegenerative diseases
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • G. DE CHIARA 1, M.E. MARCOCCI 2, L. CIVITELLI 2, R. PIACENTINI 3, C. RIPOLI 3, E. GARACI 4, C. GRASSI 3, A.T. PALAMARA 5,6 (literal)
Pagina inizio
  • 235 (literal)
Pagina fine
  • 246 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy 2Department of Public Health and Infectious Diseases, Sapienza University of Rome, , Italy, 3Institute of Human Physiology, Catholic University Medical School, Rome, Italy 4Department of Experimental Medicine and Biochemical Sciences, University \"Tor Vergata\", Rome, Italy, 5San Raffaele Pisana Scientific Institute for Research, Hospitalization and Health Care, Rome, Italy, 6Department of Public Health and Infectious Diseases, Institute Pasteur Cenci Bolognetti Foundation, Sapienza University of Rome, Italy. (literal)
Titolo
  • HSV-1 AND CNS: THE LONG TERM EFFECTS OF A LASTING AFFAIR (literal)
Abstract
  • Starting from the pioneering studies showing evidence of herpes simplex virus type-1 (HSV-1) genome in Alzheimer's disease (AD) brains, different epidemiological and experimental reports have proposed a possible connection between AD risk and HSV-1 recurrent infections. The main hypothesis is that, beyond massive HSV-1 entry in the brain, resulting in rare, but severe form of herpetic encephalitis, milder cerebral infection may also occur, followed by latency and virus reactivations, whose damages, may accumulate over life and result in pathologic outcomes in the elderly. This paper provides a review of literature supporting HSV-1 as a risk factor for neurodegeneration and showing the possible mechanisms involved (literal)
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