http://www.cnr.it/ontology/cnr/individuo/prodotto/ID230569
Protein Quality Control along the Route to the Plant Vacuole (Articolo in rivista)
- Type
- Label
- Protein Quality Control along the Route to the Plant Vacuole (Articolo in rivista) (literal)
- Anno
- 1997-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1105/tpc.9.10.1869 (literal)
- Alternative label
E. Pedrazzini, G. Giovinazzo, A. Bielli, M. de Virgilio, L.Frigerio, M. Pesca, F. Faoro, R. Bollini, A. Ceriotti, and A. Vitale (1997)
Protein Quality Control along the Route to the Plant Vacuole
in The Plant cell
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- E. Pedrazzini, G. Giovinazzo, A. Bielli, M. de Virgilio, L.Frigerio, M. Pesca, F. Faoro, R. Bollini, A. Ceriotti, and A. Vitale (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.plantcell.org/content/9/10/1869.full.pdf+html (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- EP, GG, AB, MdeV, LF, MP, RB, AC, AV: Istituto di Biologia e Biotecnologia Agraria - CNR
FF: Università degli Studi mMilano (literal)
- Titolo
- Protein Quality Control along the Route to the Plant Vacuole (literal)
- Abstract
- To acquire information on the relationships between structural maturation of proteins in the endoplasmic reticulum
(ER) and their transport along the secretory pathway, we have analyzed the destiny of an assembly-defective form of
the trimeric vacuolar storage glycoprotein phaseolin. In leaves of transgenic tobacco, where assembly-competent
phaseolin is correctly targeted to the vacuole, defective phaseolin remains located in the ER or a closely related compartment
where it represents a major ligand of the chaperone BiP. Defective phaseolin maintained susceptibility to
endoglycosidase H and was slowly degraded by a process that is not inhibited by heat shock or brefeldin A, indicating
that degradation does not involve transport along the secretory pathway. These results provide evidence for the presente
of a quality control mechanism in the ER of plant cells that avoids intracellular trafficking of severely defective
proteins and eventually leads to their degradation. (literal)
- Prodotto di
- Autore CNR
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