Protein Quality Control along the Route to the Plant Vacuole (Articolo in rivista)

Type
Label
  • Protein Quality Control along the Route to the Plant Vacuole (Articolo in rivista) (literal)
Anno
  • 1997-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1105/tpc.9.10.1869 (literal)
Alternative label
  • E. Pedrazzini, G. Giovinazzo, A. Bielli, M. de Virgilio, L.Frigerio, M. Pesca, F. Faoro, R. Bollini, A. Ceriotti, and A. Vitale (1997)
    Protein Quality Control along the Route to the Plant Vacuole
    in The Plant cell
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • E. Pedrazzini, G. Giovinazzo, A. Bielli, M. de Virgilio, L.Frigerio, M. Pesca, F. Faoro, R. Bollini, A. Ceriotti, and A. Vitale (literal)
Pagina inizio
  • 1869 (literal)
Pagina fine
  • 1880 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.plantcell.org/content/9/10/1869.full.pdf+html (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 9 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • EP, GG, AB, MdeV, LF, MP, RB, AC, AV: Istituto di Biologia e Biotecnologia Agraria - CNR FF: Università degli Studi mMilano (literal)
Titolo
  • Protein Quality Control along the Route to the Plant Vacuole (literal)
Abstract
  • To acquire information on the relationships between structural maturation of proteins in the endoplasmic reticulum (ER) and their transport along the secretory pathway, we have analyzed the destiny of an assembly-defective form of the trimeric vacuolar storage glycoprotein phaseolin. In leaves of transgenic tobacco, where assembly-competent phaseolin is correctly targeted to the vacuole, defective phaseolin remains located in the ER or a closely related compartment where it represents a major ligand of the chaperone BiP. Defective phaseolin maintained susceptibility to endoglycosidase H and was slowly degraded by a process that is not inhibited by heat shock or brefeldin A, indicating that degradation does not involve transport along the secretory pathway. These results provide evidence for the presente of a quality control mechanism in the ER of plant cells that avoids intracellular trafficking of severely defective proteins and eventually leads to their degradation. (literal)
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