Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappatà S, Barone P. (2004)
  Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease.
  in Neurology (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappatà S, Barone P. (literal)

Pagina inizio

• 2097 (literal)

Pagina fine

• 2103 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 63 (literal)

Rivista

• Neurology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Biostructure and Bioimaging Institute, National Research Council, Via S. Pansini, 5, 80131, Napoli, (literal)

Titolo

• Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease. (literal)

Abstract

• OBJECTIVE: To investigate whether the presence of parkin gene mutations is associated with different nigrostriatal impairment than other early-onset parkinsonism. METHODS: Eighteen consecutive early-onset Parkinson disease (PD) patients (nine parkin and nine nonparkin patients) and six controls were studied with [123I]FP-CIT SPECT. RESULTS: Parkin patients had longer disease duration (15 +/- 9 vs 6 +/- 2 years, p = 0.008) and higher Unified Parkinson's Disease Rating Scale (UPDRS) motor score (35.8 +/- 13.7 vs 22.8 +/- 7.9, p = 0.025) than nonparkin patients. Caudate and putamen DAT density were reduced by 60% and 79% in parkin and by 43% and 70% in nonparkin patients. Multiple regression analysis showed that the UPDRS and the presence of parkin gene mutations, but not the disease duration, were significantly correlated with the striatal DAT density. Parkin patients showed a more symmetric DAT loss in both caudate and putamen as compared with nonparkin patients. CONCLUSIONS: Parkin-related disease may be associated with a higher degree of nigrostriatal impairment, independently of the clinical severity of the disease, and a more symmetric involvement as compared with non-parkin early-onset disease. (literal)

Prodotto di

• Studio di malattie neurodegenerative con tecniche di tomografia emissiva. (ME.P02.001.002) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• ANDREA VARRONE (Persona)
• SABINA PAPPATA' (Persona)
• ARTURO BRUNETTI (Unità di personale esterno)
• MARCO SALVATORE (Persona)

Incoming links:

Autore CNR di

• ARTURO BRUNETTI (Unità di personale esterno)
• MARCO SALVATORE (Persona)
• SABINA PAPPATA' (Persona)
• ANDREA VARRONE (Persona)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Studio di malattie neurodegenerative con tecniche di tomografia emissiva. (ME.P02.001.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurology (Rivista)