http://www.cnr.it/ontology/cnr/individuo/prodotto/ID23015
In vivo carotid artery closure by laser activation of hyaluronan-embedded gold nanorods (Articolo in rivista)
- Type
- Label
- In vivo carotid artery closure by laser activation of hyaluronan-embedded gold nanorods (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1117/1.3449574 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Paolo Matteini; Fulvio Ratto; Francesca Rossi; Giuseppe Esposito; Alfredo Puca; Alessio Albanese; Giulio Maira; Roberto Pini (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- 1) Recensione su SPIE Newsroom \"Photothermal therapy used in laser bonding, microsurgery\", 7 July 2010, DOI: 10.1117/2.1201006.002890.
2) Selezionato e pubblicato sula rivista online: Virtual Journal of Nanoscale Science & Technology, 22 (3) (19 luglio 2010) (literal)
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- Rivista
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- Larticolo è stato selezionato e pubblicato online dalla rivista Vir. J. Nan. Sci. & Tech. 22 (3) (19 luglio 2010) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
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- PubMe (literal)
- Scopu (literal)
- ISI Web of Science (WOS) (literal)
- Google Scholar (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Applied Physics \"Nello Carrara\", Italian National Research Council, via Madonna del Piano, 10 - 50019 Sesto Fiorentino, Italy
University of Camerino, Faculty of Veterinary Medicine, via Circonvallazione, 93/95 - 62024 Matelica, Italy
Catholic University School of Medicine, Institute of Neurosurgery, L.go A. Gemelli, 8 - 00168 Rome, Italy (literal)
- Titolo
- In vivo carotid artery closure by laser activation of hyaluronan-embedded gold nanorods (literal)
- Abstract
- We prove the first application of near-infrared-absorbing gold nanorods (GNRs) for in vivo laser closure of a rabbit carotid artery. GNRs are first functionalized with a biopolymeric shell and then embedded in hyaluronan, which gives a stabilized and handy laser-activable formulation. Four rabbits undergo closure of a 3-mm longitudinal incision performed on the carotid artery by means of a 810-nm diode laser in conjunction with the topical application of the GNRs composite. An effective surgery is obtained by using a 40-W/cm(2) laser power density. The histological and electron microscopy evaluation after a 30-day follow-up demonstrates complete healing of the treated arteries with full re-endothelization at the site of GNRs application. The absence of microgranuloma formation and/or dystrophic calcification is evidence that no host reaction to nanoparticles interspersed through the vascular tissue occurred. The observation of a reshaping and associated blue shift of the NIR absorption band of GNRs after laser treatment supports the occurrence of a self-terminating process, and thus of additional safety of the minimally invasive laser procedure. This study underlines the feasibility of using GNRs for in vivo laser soldering applications, which represents a step forward toward the introduction of nanotechnology-based therapies in minimally invasive clinical practices. (literal)
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