In vivo carotid artery closure by laser activation of hyaluronan-embedded gold nanorods (Articolo in rivista)

Type
Label
  • In vivo carotid artery closure by laser activation of hyaluronan-embedded gold nanorods (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1117/1.3449574 (literal)
Alternative label
  • Paolo Matteini; Fulvio Ratto; Francesca Rossi; Giuseppe Esposito; Alfredo Puca; Alessio Albanese; Giulio Maira; Roberto Pini (2010)
    In vivo carotid artery closure by laser activation of hyaluronan-embedded gold nanorods
    in Journal of biomedical optics
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Paolo Matteini; Fulvio Ratto; Francesca Rossi; Giuseppe Esposito; Alfredo Puca; Alessio Albanese; Giulio Maira; Roberto Pini (literal)
Pagina inizio
  • 041508-1 (literal)
Pagina fine
  • 041508-6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • 1) Recensione su SPIE Newsroom \"Photothermal therapy used in laser bonding, microsurgery\", 7 July 2010, DOI: 10.1117/2.1201006.002890. 2) Selezionato e pubblicato sula rivista online: Virtual Journal of Nanoscale Science & Technology, 22 (3) (19 luglio 2010) (literal)
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  • 15 (literal)
Rivista
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  • L’articolo è stato selezionato e pubblicato online dalla rivista Vir. J. Nan. Sci. & Tech. 22 (3) (19 luglio 2010) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Note
  • PubMe (literal)
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
  • Google Scholar (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Applied Physics \"Nello Carrara\", Italian National Research Council, via Madonna del Piano, 10 - 50019 Sesto Fiorentino, Italy University of Camerino, Faculty of Veterinary Medicine, via Circonvallazione, 93/95 - 62024 Matelica, Italy Catholic University School of Medicine, Institute of Neurosurgery, L.go A. Gemelli, 8 - 00168 Rome, Italy (literal)
Titolo
  • In vivo carotid artery closure by laser activation of hyaluronan-embedded gold nanorods (literal)
Abstract
  • We prove the first application of near-infrared-absorbing gold nanorods (GNRs) for in vivo laser closure of a rabbit carotid artery. GNRs are first functionalized with a biopolymeric shell and then embedded in hyaluronan, which gives a stabilized and handy laser-activable formulation. Four rabbits undergo closure of a 3-mm longitudinal incision performed on the carotid artery by means of a 810-nm diode laser in conjunction with the topical application of the GNRs composite. An effective surgery is obtained by using a 40-W/cm(2) laser power density. The histological and electron microscopy evaluation after a 30-day follow-up demonstrates complete healing of the treated arteries with full re-endothelization at the site of GNRs application. The absence of microgranuloma formation and/or dystrophic calcification is evidence that no host reaction to nanoparticles interspersed through the vascular tissue occurred. The observation of a reshaping and associated blue shift of the NIR absorption band of GNRs after laser treatment supports the occurrence of a self-terminating process, and thus of additional safety of the minimally invasive laser procedure. This study underlines the feasibility of using GNRs for in vivo laser soldering applications, which represents a step forward toward the introduction of nanotechnology-based therapies in minimally invasive clinical practices. (literal)
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