Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/srep01351 (literal)

Alternative label

• Carotenuto, M ; Pedone, E ; Diana, D ; de Antonellis, P ; Dzeroski, S ; Marino, N ; Navas, L ; Di Dato, V ; Scoppettuolo, MN ; Cimmino, F ; Correale, S ; Pirone, L ; Monti, SM ; Bruder, E ; Zenko, B ; Slavkov, I ; Pastorino, F ; Ponzoni, M ; Schulte, JH ; Schramm, A ; Eggert, A; Westermann, F ; Arrigoni, G ; Accordi, B ; Basso, G ; Saviano, M ; Fattorusso, R ; Zollo, M (2013)
  Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction
  in Scientific reports (Nature Publishing Group)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Carotenuto, M ; Pedone, E ; Diana, D ; de Antonellis, P ; Dzeroski, S ; Marino, N ; Navas, L ; Di Dato, V ; Scoppettuolo, MN ; Cimmino, F ; Correale, S ; Pirone, L ; Monti, SM ; Bruder, E ; Zenko, B ; Slavkov, I ; Pastorino, F ; Ponzoni, M ; Schulte, JH ; Schramm, A ; Eggert, A; Westermann, F ; Arrigoni, G ; Accordi, B ; Basso, G ; Saviano, M ; Fattorusso, R ; Zollo, M (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 3 (literal)

Rivista

• Scientific reports (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1351 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Ctr Ingn Genet & Biotecnol Avanzate CEINGE, Naples, Italy Univ Naples Federico II, Dipartimento Med Mol & Biotecnol Med, Naples, Italy CNR, Ist Biostrutture & Bioimmagini, I-80125 Naples, Italy Univ Naples 2, Dipartimento Sci Ambientali, Caserta, Italy Univ Naples Federico II, Sez Clin Chirurg, Dipartimento Sci Clin Vet, Naples, Italy Univ Basel, Dept Pathol, Basel, Switzerland Jozef Stefan Inst, Dept Knowledge Technol, Ljubljana 1000, Slovenia Osped Pediat, Ist Giannina Gaslini, I-16148 Genoa, Italy Univ Childrens Hosp Essen, Dept Paediat Oncol & Haematol, D-45122 Essen, Germany German Canc Res Ctr, Dept Tumour Genet, Heidelberg, Germany Univ Milan, Osped San Raffaele, Dept Pathol, I-20127 Milan, Italy Univ Padua, Dept Paediat, Haematooncol Lab, Padua, Italy CNR, Ist Cristallog, I-70126 Bari, Italy NCI, Womens Canc Sect, Mol Pharmacol Lab, Bethesda, MD 20892 USA (literal)

Titolo

• Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction (literal)

Abstract

• Nm23-H1 is one of the most interesting candidate genes for a relevant role in Neuroblastoma pathogenesis. H-Prune is the most characterized Nm23-H1 binding partner, and its overexpression has been shown in different human cancers. Our study focuses on the role of the Nm23-H1/h-Prune protein complex in Neuroblastoma. Using NMR spectroscopy, we performed a conformational analysis of the h-Prune C-terminal to identify the amino acids involved in the interaction with Nm23-H1. We developed a competitive permeable peptide (CPP) to impair the formation of the Nm23-H1/h-Prune complex and demonstrated that CPP causes impairment of cell motility, substantial impairment of tumor growth and metastases formation. Meta-analysis performed on three Neuroblastoma cohorts showed Nm23-H1 as the gene highly associated to Neuroblastoma aggressiveness. We also identified two other proteins (PTPRA and TRIM22) with expression levels significantly affected by CPP. These data suggest a new avenue for potential clinical application of CPP in Neuroblastoma treatment. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• DONATELLA DIANA (Unità di personale interno)
• EMILIA MARIA PEDONE (Unità di personale interno)
• SIMONA MARIA MONTI (Unità di personale interno)

Incoming links:

Autore CNR di

• SIMONA MARIA MONTI (Unità di personale interno)
• EMILIA MARIA PEDONE (Unità di personale interno)
• DONATELLA DIANA (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Scientific reports (Rivista)