Bovine lactoferrin peptidic fragments involved in inhibition of herpes simplex virus type 1 infection (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Bovine lactoferrin peptidic fragments involved in inhibition of herpes simplex virus type 1 infection (Articolo in rivista) (literal)

Anno

• 1999-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1006/bbrc.1999.1318 (literal)

Alternative label

• Siciliano R, Rega B, Marchetti M, Seganti L, Antonini G, Valenti P. (1999)
  Bovine lactoferrin peptidic fragments involved in inhibition of herpes simplex virus type 1 infection
  in Biochemical and biophysical research communications (Print); ELSEVIER, NEW YORK (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Siciliano R, Rega B, Marchetti M, Seganti L, Antonini G, Valenti P. (literal)

Pagina inizio

• 19 (literal)

Pagina fine

• 23 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 264 (literal)

Rivista

• Biochemical and biophysical research communications (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Inst. of Food Science and Technology, CNR, I-83100 Avellino, Italy Institute of Microbiology, University of Rome la Sapienza, I-00185 Rome, Italy Dept. of Basic and Applied Biology, University of l'Aquila, I-67010 L'Aquila, Italy Institute of Microbiology, II University of Naples, I-80135 Naples, Italy (literal)

Titolo

• Bovine lactoferrin peptidic fragments involved in inhibition of herpes simplex virus type 1 infection (literal)

Abstract

• Bovine lactoferrin (BLf) prevents the infection of some enveloped and naked viruses. To identify BLf sequences responsible for the antiviral activity, we tested 31 HPLC fractions, derived from tryptic digestion of BLf, toward herpes simplex virus type 1 (HSV-1). Only a few HPLC purified fragments were active against HSV-1, even if at lower extent than the native undigested BLf. Two large fragments, one corresponding to the C-lobe (amino acid sequence 345-689) and the other corresponding to a large portion of the N-lobe (1-280), were inhibitors of HSV-1 infection, while a smaller part of the N-lobe (86-258) was ineffective. Among the low-molecular-weight fragments, only two small peptides, which coeluted in a single chromatographic peak, were effective towards HSV-1. These peptides, both present in the N-lobe, were identified as peptides 222-230 (ADRDQYELL) and 264-269 (EDLIWK). The same peptides, chemically synthesised, were able to inhibit HSV-1 infection only when they were assayed in association. (literal)

Editore

• ELSEVIER (Editore)

Prodotto di

• Metodologie di Spettrometria di Massa, Proteomica, Metabolomica e Bioinformatica nelle Scienze dell'Alimentazione (AG.P05.003.001) (Modulo)
• Institute of food sciences (ISA) (Istituto)

Autore CNR

• ROSA ANNA SICILIANO (Persona)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Metodologie di Spettrometria di Massa, Proteomica, Metabolomica e Bioinformatica nelle Scienze dell'Alimentazione (AG.P05.003.001) (Modulo)

Autore CNR di

• ROSA ANNA SICILIANO (Persona)

Editore di

• ELSEVIER (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biochemical and biophysical research communications (Rivista)