The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, regulates hippocampal aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its \"anti-alcohol\" and anxiolytic properties (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, regulates hippocampal aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its \"anti-alcohol\" and anxiolytic properties (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Alternative label

• Ferraro L., Loche A., Beggiato S., Tomasini M.C., Antonelli T., Colombo G., Lobina C., Carai M.A.M., Porcu A., Castelli M.P., Clerici F., Borrelli A.C., Cacciaglia R., Tanganelli S. (2013)
  The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, regulates hippocampal aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti-alcohol" and anxiolytic properties
  in Current medicinal chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ferraro L., Loche A., Beggiato S., Tomasini M.C., Antonelli T., Colombo G., Lobina C., Carai M.A.M., Porcu A., Castelli M.P., Clerici F., Borrelli A.C., Cacciaglia R., Tanganelli S. (literal)

Pagina inizio

• 3339 (literal)

Pagina fine

• 3357 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 20 (literal)

Rivista

• Current medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 19 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 27 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Life Sciences and Biotechnology (SVEB), University of Ferrara, Italy; Laboratory for the Technology of Advanced Therapies (LTTA Centre), University of Ferrara, Italy; Laboratorio CT srl, Sanremo, Italy; Department of Medical Sciences, University of Ferrara; Italy; Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Monserrato, Cagliari, Italy; Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Italy; Department of Pharmaceutical Sciences, University of Milan, Italy (literal)

Titolo

• The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, regulates hippocampal aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its \"anti-alcohol\" and anxiolytic properties (literal)

Abstract

• The present article attempts to provide, on the basis of data emerging from studies carried out in our laboratories, a summary of the chemical and pharmacological properties of the new compound N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide (GET73). Particular emphasis is given to findings obtained in vivo and in vitro suggesting that an allosteric modulation of metabotropic glutamate receptor 5 (mGlu5 receptor) by GET73 may represent the mechanism underlying the effects of the compound produced on rat hippocampal glutamate and GABA transmission. Furthermore, behavioural findings demonstrating how this new compound reduces alcohol intake, displays anxiolytic properties, and influences spatial memory in rats are also summarized. Since mGlu5 receptors play an important role in regulating several central actions of drugs of abuse, and the hippocampus is a crucial brain area involved in addiction, anxiety, and spatial memory, a possible link between mGlu5 receptor allosteric modulation and the profiles of action of GET73 is proposed, although to date no studies have yet explored GET73 binding at the mGlu5 receptor orthosteric and/or allosteric sites. Following a brief overview of glutamatergic neurotransmission, mGlu receptor structures and activation mechanisms, the general properties of mGlu5 receptor and its allosteric modulators are described in the first part of the review. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Autore CNR

• CARLA LOBINA (Persona)
• MAURO ANTONIO MARIA CARAI (Unità di personale esterno)
• GIANCARLO COLOMBO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, regulates hippocampal aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its \"anti-alcohol\" and anxiolytic properties" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• GIANCARLO COLOMBO (Unità di personale interno)
• MAURO ANTONIO MARIA CARAI (Unità di personale esterno)
• CARLA LOBINA (Persona)

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Neurobiologia dell'alcolismo (ME.P02.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current medicinal chemistry (Rivista)

Insieme di parole chiave di

• Parole chiave di "The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, regulates hippocampal aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its \"anti-alcohol\" and anxiolytic properties" (Insieme di parole chiave)