http://www.cnr.it/ontology/cnr/individuo/prodotto/ID228630
In Vitro Activity of the alpha(v)beta(3) Integrin Antagonist RGDechi-hCit on Malignant Melanoma Cells (Articolo in rivista)
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- Label
- In Vitro Activity of the alpha(v)beta(3) Integrin Antagonist RGDechi-hCit on Malignant Melanoma Cells (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Alternative label
Pisano, M; De Paola, I; Nieddu, V; Sassu, I; Cossu, S; Galleri, G; Del Gatto, A; Budroni, M ; Cossu, A ; Saviano, M ; Palmieri, G ; Zaccaro, L ; Rozzo, C. (2013)
In Vitro Activity of the alpha(v)beta(3) Integrin Antagonist RGDechi-hCit on Malignant Melanoma Cells
in Anticancer research
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pisano, M; De Paola, I; Nieddu, V; Sassu, I; Cossu, S; Galleri, G; Del Gatto, A; Budroni, M ; Cossu, A ; Saviano, M ; Palmieri, G ; Zaccaro, L ; Rozzo, C. (literal)
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- Natl Res Council Italy, Inst Biomol Chem, Sassari, Italy
Natl Res Council Italy, Inst Biostruct & Bioimaging, Sassari, Italy
Sardinia Res Labs Porto Conte Ric, Alghero, Italy
Serv Epidemiol, Local Hlth Unit 1, Sassari, Italy
Inst Pathol, Univ Hlth Unit, Sassari, Italy
Natl Res Council Italy, Inst Crystallog, Bari, Italy (literal)
- Titolo
- In Vitro Activity of the alpha(v)beta(3) Integrin Antagonist RGDechi-hCit on Malignant Melanoma Cells (literal)
- Abstract
- Background: In malignant melanoma (MM), overexpression of alpha(v)beta(3) integrin is linked to a more metastatic phenotype. Development of anti-alpha(v)beta(3) agents able to counteract melanoma progression would be helpful for disease treatment. A new selective ligand of alpha(v)beta(3), RGDechi-hCit, has anti-angiogenic properties against endothelial cells in animal angiogenesis models. The aim of this study was to evaluate the in vitro effects of the RGDechi-hCit peptide on MM cell lines. Materials and Methods: Cytofluorimetric analysis characterized the cell surface expression of alpha(v)beta(3) integrin on seven MM cell lines: A375, WM266-4, SK-Mel-28, Sbcl2, LB24Dagi, PR-Mel and PNP-Mel. Cell proliferation, adhesion, and migration assays were carried out using the alpha(v)beta(3)-antagonist RGDechi-hCit. Results: Proliferation was not significantly inhibited by RGDechi-hCit, although striking morphological changes were detected in MM cell lines highly expressing alpha(v)beta(3). Conversely, assays on fibronectin-coated plates showed a significant RGDechi-hCit dose-dependent inhibitory effect on both adhesion and migration. Conclusion: The data demonstrate anti-adhesion and anti-migration, but not antiproliferative, activities of RGDechi-hCit against MM cells (literal)
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