http://www.cnr.it/ontology/cnr/individuo/prodotto/ID228034

N-Linked glycans of proteins from mitral valves of normal pigs and pigs affected by endocardiosis. (Articolo in rivista)

Type

Label

N-Linked glycans of proteins from mitral valves of normal pigs and pigs affected by endocardiosis. (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Amoresano A, Amedeo S, D'andrea G, Siciliano R, Gagna C, Castagnaro M, Marino G, Guarda F. (2000)
N-Linked glycans of proteins from mitral valves of normal pigs and pigs affected by endocardiosis.
in European journal of biochemistry (Print); Wiley-Blackwell, Oxford (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Amoresano A, Amedeo S, D'andrea G, Siciliano R, Gagna C, Castagnaro M, Marino G, Guarda F. (literal)

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

a Ctro. Internazionale di Servizi, CNR-Università, Napoli, Italy b CEINGE S.C.R.L. Biotecnologie A., Napoli, Italy c Istituto Scienze dell'Alimentazione, CNR, Avellino, Italy d Intl. Mass Spectrom. Facilities Ctr., via Pansini 5, 80131 Napoli, Italy (literal)

Titolo

N-Linked glycans of proteins from mitral valves of normal pigs and pigs affected by endocardiosis. (literal)

Abstract

Endocardiosis, a degenerative and dystrophic process affecting cardiac valves and described in many mammalian species, is characterized by the accumulation of glycosaminoglycans, in particular hyaluronic acid, in the extracellular matrix. The glycoprotein patterns of pig mitral valves in normal animals and animals affected by endocardiosis were investigated. A different N-linked glycosylation pattern of glycoproteins was detected in affected valves compared with normal ones. In either normal or pathological species, the detected N-linked glycans were of the complex type. However, in samples from affected valves, sialic acid showed a prevalence of the ?2,6 linkage to the galactosyl residue, whereas in normal samples the most frequent linkage was of the ?2,3 type. In normal valves, the majority of complex oligosaccharides presented two outer branches with different degrees of fucosylation and sialylation, whereas in pathological samples we noted an increased number of glycans having up to four outer branches. (literal)

Editore