http://www.cnr.it/ontology/cnr/individuo/prodotto/ID227038
Developmental changes of neuron-specific enolase mRNA in primary cultures of rat neurons. (Articolo in rivista)
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- Developmental changes of neuron-specific enolase mRNA in primary cultures of rat neurons. (Articolo in rivista) (literal)
- Anno
- 1991-01-01T00:00:00+01:00 (literal)
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Di Liegro I 1, Cestelli A 1, Barbieri G 1, Giallongo A 2. (1991)
Developmental changes of neuron-specific enolase mRNA in primary cultures of rat neurons.
in Cellular and molecular neurobiology; Plenum Press, New York (Stati Uniti d'America)
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- Di Liegro I 1, Cestelli A 1, Barbieri G 1, Giallongo A 2. (literal)
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- 1 Dipartimento di Biologia Cellulare e dello Sviluppo \"Alberto Monroy\", Università degli Studi, Via Archirafi 22, 90123 Palermo, Italy
2 Istituto di Biologia dello Sviluppo, Consiglio Nazionale delle Ricerche Via Archirafi 20, 90123 Palermo, Italy. (literal)
- Titolo
- Developmental changes of neuron-specific enolase mRNA in primary cultures of rat neurons. (literal)
- Abstract
- 1. The level of mRNAs for neuron-specific enolase (NSE) and nonneuronal enolase (NNE) was studied in developing rat brain and in pure neuronal cultures of corresponding ages treated or not treated with triiodothyronine (T3). 2. In brain cortices both messages are already detectable at the earliest age (embryonal day 16; E16). During development the mRNA for NNE remains at a steady level, with a transient decline at postnatal day 5 (P5). 3. On the other hand, NSE mRNA follows a biphasic curve: the signal increases threefold from E-16 to P0 and threefold from P5 to P18, with a plateau between P0 and P5. 4. In neuronal cultures the NNE message is present at a constant level until day 10 and declines sharply thereafter, while in T3-treated cultures it reaches a minimum beforehand. 5. The NSE mRNA, on the other hand, increases continuously throughout the whole culture life span, and a slightly higher level is observed in T3-treated cells during the first ten days. (literal)
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