http://www.cnr.it/ontology/cnr/individuo/prodotto/ID223864
New Amphiphilic Conjugates of Amino-Poly(ethylene glycols) With Lipoamino Acids as Surface Modifiers of Colloidal Drug Carriers (Articolo in rivista)
- Type
- Label
- New Amphiphilic Conjugates of Amino-Poly(ethylene glycols) With Lipoamino Acids as Surface Modifiers of Colloidal Drug Carriers (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/macp.201200476 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pignatello Rosario; Pantò Valentina; Impallomeni Giuseppe; Carnemolla Giovanni Marco; Carbone Claudia; Puglisi Giovanni (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Univ Catania, Dipartimento Sci Farmaco, I-95125 Catania, Italy (literal)
- Titolo
- New Amphiphilic Conjugates of Amino-Poly(ethylene glycols) With Lipoamino Acids as Surface Modifiers of Colloidal Drug Carriers (literal)
- Abstract
- Poly(ethylene glycol) (PEG2000) polymers containing one or two amine residues are linked to a-lipoamino acids (LAA) to produce mono- and homo-disubstituted PEGLAA conjugates as new materials for the surface coating of colloidal drug carriers. Conjugates are characterized by FT-IR, 1H-NMR, and MALDITOF mass spectrometry. Differential scanning calorimetry studies are performed to assess the interaction of PEG2000LAAs with a biomembrane model (dipalmitoylphosphatidylcholine multilamellar liposomes). Whereas the parent PEGs affect only the superficial structure of the bilayers, the amphiphilic PEGLAA conjugates exert a modulated perturbing effect on the thermotropic profile of liposomes. A molar concentration between 5% and 10% is individuated as the more suitable to produce stable vesicles. (literal)
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