Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 (Articolo in rivista)

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  • Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 (Articolo in rivista) (literal)
Anno
  • 1994-01-01T00:00:00+01:00 (literal)
Alternative label
  • Lutticken C 1, Wegenka UM 1, Yuan J 1, Buschmann J 1, Schindler C 2, Ziemiecki A 3, Harpur AG 4, Wilks AF 4, Yasukawa K 5, Taga T 6, Kishimoto T 7, Barbieri G 8, Pellegrini S 8, Sendtner M 9, Heinrich PC 1 and Horn F 1. (1994)
    Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130
    in Science (New York, N.Y.); AAAS, American association for the advancement of science, Washington, DC (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lutticken C 1, Wegenka UM 1, Yuan J 1, Buschmann J 1, Schindler C 2, Ziemiecki A 3, Harpur AG 4, Wilks AF 4, Yasukawa K 5, Taga T 6, Kishimoto T 7, Barbieri G 8, Pellegrini S 8, Sendtner M 9, Heinrich PC 1 and Horn F 1. (literal)
Pagina inizio
  • 89 (literal)
Pagina fine
  • 92 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 263 (literal)
Rivista
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  • 3 (literal)
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  • 5143 (literal)
Note
  • Google Scholar (literal)
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  • 1 Institute for Biochemistry, RWTH Aachen, Pauwelsstrasse 30 D-52057 Aachen, Germany. 2 College of Physicians and Surgeons of Columbia University, Department of Medicine, New York, NY 10032. 3 Laboratory for Clinical and Experimental Cancer Research, University of Berne, Tiefenaustrasse 120, CH-3004 Bern, Switzerland. 4 Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia. 5 Biotechnology Research Laboratory, Tosoh Corporation, 2743-1 Hayakawa, Ayase Kanagawa 252, Japan. 6 Institute for Molecular and Cellular Biology, Osaka University, 1-3, Yamadaoka, Suita, Osaka 565, Japan. 7 Department of Medicine III, Osaka University Medical School 2-2, Yamadaoka, Suita, Osaka 565, Japan. 8 Unité INSERM 276, Institut Pasteur, 75724, CEDEX 15, Paris, France. 9 Max Planck Institute for Psychiatry, Am Klopferspitz, D-82152, Martinsried, Germany (literal)
Titolo
  • Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 (literal)
Abstract
  • Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenically related to the p91 subunit of the interferon-stimulated gene factor-3 alpha (ISGF-3 alpha). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3 alpha p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp130. (literal)
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