http://www.cnr.it/ontology/cnr/individuo/prodotto/ID223465

Goosecoid HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. (Articolo in rivista)

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Goosecoid HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. (Articolo in rivista) (literal)

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FILOSA S, RIVERA-PEREZ JA, GOMEZ AP, GANSMULLER A, SASAKI H, BEHRINGER RR, ANG SL (1997)
Goosecoid HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis.
in Development (Camb.); Company of biologists, Cambridge (Regno Unito)
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FILOSA S, RIVERA-PEREZ JA, GOMEZ AP, GANSMULLER A, SASAKI H, BEHRINGER RR, ANG SL (literal)

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[ 1 ] UNIV STRASBOURG 1,COLL FRANCE,INSERM,CNRS,INST GENET & BIOL MOL & CELLULAIRE,F-67404 ILLKIRCH GRAFFENS,CU STRASBOURG,FRANCE [ 2 ] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT MOL GENET,HOUSTON,TX 77030 [ 3 ] OSAKA UNIV,INST MOL & CELLULAR BIOL,DEV BIOL LAB,OSAKA 565,JAPAN (literal)

Titolo

Goosecoid HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. (literal)

Abstract

The homeobox gene goosecoid (gsc) and the winged-helix gene Hepatic Nuclear Factor-3 beta (HNF-3 beta) are co-expressed in all three germ layers in the anterior primitive streak and at the rostral end of mouse embryos during gastrulation. In this paper, we have tested the possibility of functional synergism or redundancy between these two genes during embryogenesis by generating double-mutant mice for gsc and HNF-3 beta. Double-mutant embryos of genotype gsc(-/-); HNF-3 beta(+/-) show a new phenotype as early as embryonic days 8.75, Loss of Sonic hedgehog (Shh) and HNF-3 beta expression was observed in the notochord and ventral neural tube of these embryos. These results indicate that gsc and HNF-3 beta interact to regulate Shh expression and consequently dorsal-ventral patterning in the neural tube. In the forebrain of the mutant embryos, severe growth defects and absence of optic vesicles could involve loss of expression of fibroblast growth factor-8, in addition to Shh, Our results also suggest that interaction between gsc and HNF-3 beta regulates other signalling molecules required for proper development of the foregut, branchial arches and heart. (literal)

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