HSV-1 promotes Ca2+ -mediated APP phosphorylation and Abeta accumulation in rat cortical neurons (Articolo in rivista)

Type
Label
  • HSV-1 promotes Ca2+ -mediated APP phosphorylation and Abeta accumulation in rat cortical neurons (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.neurobiolaging.2010.06.009 (literal)
Alternative label
  • Roberto Piacentini a,1, Livia Civitelli b,1, Cristian Ripolia,1, Maria Elena Marcocci b, Giovanna De Chiara c, Enrico Garaci d, Gian Battista Azzena a, Anna Teresa Palamara e,f, Claudio Grassi a,* (2011)
    HSV-1 promotes Ca2+ -mediated APP phosphorylation and Abeta accumulation in rat cortical neurons
    in Neurobiology of aging
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Roberto Piacentini a,1, Livia Civitelli b,1, Cristian Ripolia,1, Maria Elena Marcocci b, Giovanna De Chiara c, Enrico Garaci d, Gian Battista Azzena a, Anna Teresa Palamara e,f, Claudio Grassi a,* (literal)
Pagina inizio
  • 2323.e13 (literal)
Pagina fine
  • 2323.e26 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 32 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Institute of Human Physiology, Catholic University Medical School, Rome, Italy b Department of Public Health Sciences, Sapienza University of Rome, Rome, Italy c Department of Cell Biology and Neuroscience, ISS, Rome, Italy d Department of Experimental Medicine and Biochemical Sciences, University of Rome \"Tor Vergata\", Rome, Italy e Department of Public Health and Infectious Diseases, Institute Pasteur Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy f San Raffaele Pisana Scientific Institute for Research, Rome, Italy (literal)
Titolo
  • HSV-1 promotes Ca2+ -mediated APP phosphorylation and Abeta accumulation in rat cortical neurons (literal)
Abstract
  • Epidemiological and experimental findings suggest that chronic infection with Herpes simplex virus type 1 (HSV-1) may be a risk factor for Alzheimer's disease (AD), but the molecular mechanisms underlying this association have not been fully identified. We investigated the effects of HSV-1 on excitability and intracellular calcium signaling in rat cortical neurons and the impact of these effects on amyloid precursor protein (APP) processing and the production of amyloid-beta peptide (Abeta). Membrane depolarization triggering firing rate increases was observed shortly after neurons were challenged with HSV-1 and was still evident 12 hours postinfection. These effects depended on persistent sodium current activation and potassium current inhibition. The virally induced hyperexcitability triggered intracellular Ca2+ signals that significantly increased intraneuronal Ca2+ levels. It also enhanced activity- and Ca2+-dependent APP phosphorylation and intracellular accumulation of Abeta42. These findings indicate that HSV-1 causes functional changes in cortical neurons that promote APP processing and Abeta production, and they are compatible with the co-factorial role for HSV-1 in the pathogenesis of AD suggested by previous findings. (literal)
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