http://www.cnr.it/ontology/cnr/individuo/prodotto/ID222209
Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease (Articolo in rivista)
- Type
- Label
- Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease (Articolo in rivista) (literal)
- Anno
- 1998-01-01T00:00:00+01:00 (literal)
- Alternative label
Maiorano E, Perlino E, Triggiani V, Nacchiero M, Giove E, Ciampolillo A. (1998)
Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease
in International Journal of Molecular Medicine
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Maiorano E, Perlino E, Triggiani V, Nacchiero M, Giove E, Ciampolillo A. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Titolo
- Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease (literal)
- Abstract
- Growth factors are frequently involved in the regulation of mitosis and differentiation of several cell types and insulin-like growth factor-1 (IGF-1) is actively involved in the thyroid stimulating hormone-mediated proliferation of thyrocytes. In view of the pivotal role of IGF-1 in thyrocyte proliferation and of the still unsettled role of this growth factor in the pathogenesis of hyperplastic thyroid lesions, we investigated the expression of IGF-1 and of its corresponding receptor, by means of immunohistochemistry, in the surgical specimens obtained from six patients with Graves' disease. Moreover, IGF-1 mRNA expression was analysed in one such case by means of Northern hybridisation. All samples showed consistent intracytoplasmic immunoreactivity for both IGF-1 and IGF-1 receptor; the vast majority of hyperplastic thyrocytes were strongly decorated by the two antibodies used in this study whereas stromal cells displayed IGF-1 immunoreactivity only. IGF-1 mRNA was markedly overexpressed in Graves' disease in comparison with normal thyroid tissues. The results of this study suggest that IGF-1 and IGF-1 receptor may be actively involved in the pathogenesis of Graves' disease; furthermore, IGF-1 and IGF-1 receptor apparently act by different mechanisms (paracrine vs. autocrine) as suggested by their differential expression in epithelial and stromal cells. (literal)
- Autore CNR
Incoming links:
- Autore CNR di
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi