Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease (Articolo in rivista)

Type
Label
  • Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease (Articolo in rivista) (literal)
Anno
  • 1998-01-01T00:00:00+01:00 (literal)
Alternative label
  • Maiorano E, Perlino E, Triggiani V, Nacchiero M, Giove E, Ciampolillo A. (1998)
    Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease
    in International Journal of Molecular Medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Maiorano E, Perlino E, Triggiani V, Nacchiero M, Giove E, Ciampolillo A. (literal)
Pagina inizio
  • 483 (literal)
Pagina fine
  • 486 (literal)
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  • 2 (literal)
Rivista
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  • 4 (literal)
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  • 4 (literal)
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  • CNR (literal)
Titolo
  • Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease (literal)
Abstract
  • Growth factors are frequently involved in the regulation of mitosis and differentiation of several cell types and insulin-like growth factor-1 (IGF-1) is actively involved in the thyroid stimulating hormone-mediated proliferation of thyrocytes. In view of the pivotal role of IGF-1 in thyrocyte proliferation and of the still unsettled role of this growth factor in the pathogenesis of hyperplastic thyroid lesions, we investigated the expression of IGF-1 and of its corresponding receptor, by means of immunohistochemistry, in the surgical specimens obtained from six patients with Graves' disease. Moreover, IGF-1 mRNA expression was analysed in one such case by means of Northern hybridisation. All samples showed consistent intracytoplasmic immunoreactivity for both IGF-1 and IGF-1 receptor; the vast majority of hyperplastic thyrocytes were strongly decorated by the two antibodies used in this study whereas stromal cells displayed IGF-1 immunoreactivity only. IGF-1 mRNA was markedly overexpressed in Graves' disease in comparison with normal thyroid tissues. The results of this study suggest that IGF-1 and IGF-1 receptor may be actively involved in the pathogenesis of Graves' disease; furthermore, IGF-1 and IGF-1 receptor apparently act by different mechanisms (paracrine vs. autocrine) as suggested by their differential expression in epithelial and stromal cells. (literal)
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