Expression of univin, a TGF-? growth factor, requires ectoderm-ECM interaction and promotes skeletal growth in the sea urchin embryo (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Expression of univin, a TGF-? growth factor, requires ectoderm-ECM interaction and promotes skeletal growth in the sea urchin embryo (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Zito, F.a, Costa, C.a, Sciarrino, S.a, Poma, V.a, Russo, R.a, Angerer, L.M.b, Matranga, V.a (2003)
  Expression of univin, a TGF-? growth factor, requires ectoderm-ECM interaction and promotes skeletal growth in the sea urchin embryo
  in Developmental biology (Print); Elsevier Inc., San Diego (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Zito, F.a, Costa, C.a, Sciarrino, S.a, Poma, V.a, Russo, R.a, Angerer, L.M.b, Matranga, V.a (literal)

Pagina inizio

• 217 (literal)

Pagina fine

• 227 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 264 (literal)

Rivista

• Developmental biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Ist. Biomedicina Immunol. Molec. A., Sezione Biologia dello Sviluppo, Consiglio Nazionale delle Ricerche, Palermo, Italy b Department of Biology, University of Rochester, Rochester, NY 14627, United States (literal)

Titolo

• Expression of univin, a TGF-? growth factor, requires ectoderm-ECM interaction and promotes skeletal growth in the sea urchin embryo (literal)

Abstract

• Pl-nectin is an ECM protein located on the apical surface of ectoderm cells of Paracentrotus lividus sea urchin embryo. Inhibition of ECM-ectoderm cell interaction by the addition of McAb to Pl-nectin to the culture causes a dramatic impairment of skeletogenesis, offering a good model for the study of factor(s) involved in skeleton elongation and patterning. We showed that skeleton deficiency was not due to a reduction in the number of PMCs ingressing the blastocoel, but it was correlated with a reduction in the number of Pl-SM30-expressing PMCs. Here, we provide evidence on the involvement of growth factor(s) in skeleton morphogenesis. Skeleton-defective embryos showed a strong reduction in the levels of expression of Pl-univin, a growth factor of the TGF-? superfamily, which was correlated with an equivalent strong reduction in the levels of Pl-SM30. In contrast, expression levels of Pl-BMP5-7 remained low and constant in both skeleton-defective and normal embryos. Microinjection of horse serum in the blastocoelic cavity of embryos cultured in the presence of the antibody rescued skeleton development. Finally, we found that misexpression of univin is also sufficient to rescue defects in skeleton elongation and SM30 expression caused by McAb to Pl-nectin, suggesting a key role for univin or closely related factor in sea urchin skeleton morphogenesis. © 2003 Elsevier Inc. All rights reserved. (literal)

Editore

• Elsevier Inc. (Editore)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• SERAFINA SCIARRINO (Unità di personale interno)

Incoming links:

Autore CNR di

• SERAFINA SCIARRINO (Unità di personale interno)

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Editore di

• Elsevier Inc. (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Developmental biology (Rivista)