MePR: A Novel Human Mesenchymal Progenitor Model with Characteristics of Pluripotency. (Articolo in rivista)

Type
Label
  • MePR: A Novel Human Mesenchymal Progenitor Model with Characteristics of Pluripotency. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Alternative label
  • Miceli M, Franci G, Dell'aversana C, Ricciardiello F, Petraglia F, Carissimo A, Perone L, Maruotti GM, Savarese M, Martinelli P, Cancemi M, Altucci L. (2013)
    MePR: A Novel Human Mesenchymal Progenitor Model with Characteristics of Pluripotency.
    in Stem cells and development
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Miceli M, Franci G, Dell'aversana C, Ricciardiello F, Petraglia F, Carissimo A, Perone L, Maruotti GM, Savarese M, Martinelli P, Cancemi M, Altucci L. (literal)
Pagina inizio
  • e pub (literal)
Rivista
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università di Napoli, Napoli, Italy. Institute of Genetics and Biophysics Adriano Buzzati-Traverso, IGB-CNR, Napoli, Italy. Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy. Department of Gynaecology and Obstetrics, High-Risk Pregnancy and Prenatal Diagnosis Centre, Federico II University, Naples, Italy. Center 'Ricerche e Diagnosi Genetiche,' Naples, Italy. (literal)
Titolo
  • MePR: A Novel Human Mesenchymal Progenitor Model with Characteristics of Pluripotency. (literal)
Abstract
  • Human embryo stem cells or adult tissues are excellent models for discovery and characterization of differentiation processes. The aims of regenerative medicine are to define the molecular and physiological mechanisms that govern stem cells and differentiation. Human mesenchymal stem cells (hMSCs) are multipotent adult stem cells that are able to differentiate into a variety of cell types under controlled conditions both in vivo and in vitro, and they have the remarkable ability of self-renewal. hMSCs derived from amniotic fluid and characterized by the expression of Oct-4 and Nanog, typical markers of pluripotent cells, represent an excellent model for studies on stemness. Unfortunately, the limited amount of cells available from each donation and, above all, the limited number of replications do not allow for detailed studies. Here, we report on the immortalization and characterization of novel mesenchymal progenitor (MePR) cell lines from amniotic fluid-derived hMSCs, whose biological properties are similar to primary amniocytes. Our data indicate that MePR cells display the multipotency potential and differentiation rates of hMSCs, thus representing a useful model to study both mechanisms of differentiation and pharmacological approaches to induce selective differentiation. In particular, MePR-2B cells, which carry a bona fide normal karyotype, might be used in basic stem cell research, leading to the development of new approaches for stem cell therapy and tissue engineering. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it