Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2. (Articolo in rivista)

Type
Label
  • Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.1302107110 (literal)
Alternative label
  • Acunzo M, Romano G, Palmieri D, Laganá A, Garofalo M, Balatti V, Drusco A, Chiariello M, Nana-Sinkam P and Croce CM (2013)
    Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2.
    in Proc. natl. Acad. Sci. USA
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Acunzo M, Romano G, Palmieri D, Laganá A, Garofalo M, Balatti V, Drusco A, Chiariello M, Nana-Sinkam P and Croce CM (literal)
Pagina inizio
  • 8573 (literal)
Pagina fine
  • 8578 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.pnas.org/content/110/21/8573.long (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 110 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210; Istituto Toscano Tumori Core Research Laboratory and Consiglio Nazionale delle Ricerche IFC, 53100 Siena, Italy; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Dorothy M. Davis Heart and Lung Research Institute, Columbus, OH 43210 (literal)
Titolo
  • Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2. (literal)
Abstract
  • In the past decade, we have observed exciting advances in lung cancer therapy, including the development of targeted therapies. However, additional strategies for early detection and tumor-based therapy are still essential in improving patient outcomes. EGF receptor (EGFR) and MET (the receptor tyrosine kinase for hepatocyte growth factors) are cell-surface tyrosine kinase receptors that have been implicated in diverse cellular processes and as regulators of several microRNAs (miRNAs), thus contributing to tumor progression. Here, we demonstrate a biological link between EGFR, MET, and the miRNA cluster 23a~27a~24-2. We show that miR-27a regulates MET, EGFR, and Sprouty2 in lung cancer. In addition, we identify both direct and indirect mechanisms by which miR-27a can regulate both MET and EGFR. Thus, we propose a mechanism for MET and EGFR axis regulation that may lead to the development of therapeutics in lung cancer. (literal)
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