Effect of substance P on uterine mast cell cytokine release during the reproductive cycle. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Effect of substance P on uterine mast cell cytokine release during the reproductive cycle. (Articolo in rivista) (literal)

Anno

• 1995-01-01T00:00:00+01:00 (literal)

Alternative label

• Cocchiara R, Albeggiani G, Azzolina A, Bongiovanni A, Lampiasi N, Di Blasi F, Geraci D. (1995)
  Effect of substance P on uterine mast cell cytokine release during the reproductive cycle.
  in Journal of neuroimmunology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cocchiara R, Albeggiani G, Azzolina A, Bongiovanni A, Lampiasi N, Di Blasi F, Geraci D. (literal)

Pagina inizio

• 107 (literal)

Pagina fine

• 115 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 60 (literal)

Rivista

• Journal of neuroimmunology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IBIM (literal)

Titolo

• Effect of substance P on uterine mast cell cytokine release during the reproductive cycle. (literal)

Abstract

• There is increasing evidence that neuropeptides, steroid hormones and inflammatory cytokines influence the immune response during the reproductive cycle. In the present study, we focus on the effects of neuropeptide Substance P (SP) during the pre-implantation stage of embryo development (day 4 of pregnancy), at pro-estrus and di-estrus (two phases with different hormonal states). We found heterogeneous responses to SP and anti-IgE by the rat uterine mast cells (MCs), as detected by ELISA. In fact, MCs purified from uteri on day 4 of pregnancy released histamine, granulocyte macrophage-colony stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF-alpha) in response to anti-IgE, but not to SP. When pre-incubated with SP, the release to anti-IgE was significantly enhanced compared to anti-IgE alone. Exposure of SP to antibodies to SP, prior to pre-incubation with MCs, negated the SP effect on IgE-mediated release. At the pro-estrus phase SP showed similar behavior as on day 4 of pregnancy, whereas at the di-estrus phase SP alone was capable of inducing release of histamine and cytokines from purified uterine MCs. Moreover, non-quantitative RT-PCR analysis of the TNF-alpha mRNA level suggested an SP stimulation at the di-estrus phase, but neither on day 4 of pregnancy nor at the pro-estrus phase. Taken together, these data strongly suggest that SP can modulate IgE-mediated uterine MC release of histamine and inflammatory cytokines in different ways, depending on the phase of the reproductive cycle. (literal)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• ANTONELLA BONGIOVANNI (Persona)
• FRANCESCO DI BLASI (Unità di personale interno)
• NADIA LAMPIASI (Unità di personale interno)

Incoming links:

Autore CNR di

• FRANCESCO DI BLASI (Unità di personale interno)
• NADIA LAMPIASI (Unità di personale interno)
• ANTONELLA BONGIOVANNI (Persona)

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neuroimmunology (Rivista)