Small molecules interacting with alpha-synuclein: antiaggregating and cytoprotective properties (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Small molecules interacting with alpha-synuclein: antiaggregating and cytoprotective properties (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00726-013-1503-3 (literal)

Alternative label

• Marchiani, Anna; Mammi, Stefano; Siligardi, Giuliano; Hussain, Rohanah; Tessari, Isabella; Bubacco, Luigi; Delogu, Giovanna; Fabbri, Davide; Dettori, Maria A.; Sanna, Daniele; Dedola, Sonia; Serra, Pier A.; Ruzza, Paolo (2013)
  Small molecules interacting with alpha-synuclein: antiaggregating and cytoprotective properties
  in Amino acids (Wien, Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Marchiani, Anna; Mammi, Stefano; Siligardi, Giuliano; Hussain, Rohanah; Tessari, Isabella; Bubacco, Luigi; Delogu, Giovanna; Fabbri, Davide; Dettori, Maria A.; Sanna, Daniele; Dedola, Sonia; Serra, Pier A.; Ruzza, Paolo (literal)

Pagina inizio

• 327 (literal)

Pagina fine

• 338 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 45 (literal)

Rivista

• Amino acids (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Consiglio Nazionale delle Ricerche (CNR); University of Padua; STFC Rutherford Appleton Laboratory; University of Padua; Consiglio Nazionale delle Ricerche (CNR); University of Sassari (literal)

Titolo

• Small molecules interacting with alpha-synuclein: antiaggregating and cytoprotective properties (literal)

Abstract

• Curcumin, a dietary polyphenol, has shown a potential to act on the symptoms of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, as a consequence of its antioxidant, anti-inflammatory and anti-protein aggregation properties. Unfortunately, curcumin undergoes rapid degradation at physiological pH into ferulic acid, vanillin and dehydrozingerone, making it an unlikely drug candidate. Here, we evaluated the ability of some curcumin by-products: dehydrozingerone (1), its O-methyl derivative (2), zingerone (3), and their biphenyl analogues (4-6) to interact with alpha-synuclein (AS), using CD and fluorescence spectroscopy. In addition, the antioxidant properties and the cytoprotective effects in rat pheochromocytoma (PC12) cells prior to intoxication with H2O2, MPP+ and MnCl2 were examined while the Congo red assay was used to evaluate the ability of these compounds to prevent aggregation of AS. We found that the biphenyl zingerone analogue (6) interacts with high affinity with AS and also displays the best antioxidant properties while the biphenyl analogues of dehydrozingerone (4) and of O-methyl-dehydrozingerone (5) are able to partially inhibit the aggregation process of AS, suggesting the potential role of a hydroxylated biphenyl scaffold in the design of AS aggregation inhibitors. (literal)

Prodotto di

• Sintesi di molecole multifunzionali a rigidita' conformazionale modulabile per il trattamento delle malattie neurodegenerative (PM.P01.011.004) (Modulo)
• Istituto di chimica biomolecolare (ICB) (Istituto)
• Coniugati peptidici di farmaci e diagnostici per i tumori (PM.P01.021.002) (Modulo)

Autore CNR

• PAOLO RUZZA (Persona)
• DANIELE SANNA (Persona)
• MARIA ANTONIETTA DETTORI (Unità di personale interno)
• DAVIDE GAETANO FABBRI (Unità di personale interno)
• GIOVANNA MARIA DELOGU (Persona)

Insieme di parole chiave

• Keywords of "Small molecules interacting with alpha-synuclein: antiaggregating and cytoprotective properties" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA ANTONIETTA DETTORI (Unità di personale interno)
• DAVIDE GAETANO FABBRI (Unità di personale interno)
• GIOVANNA MARIA DELOGU (Persona)
• DANIELE SANNA (Persona)
• PAOLO RUZZA (Persona)

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Coniugati peptidici di farmaci e diagnostici per i tumori (PM.P01.021.002) (Modulo)
• Sintesi di molecole multifunzionali a rigidita' conformazionale modulabile per il trattamento delle malattie neurodegenerative (PM.P01.011.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Amino acids (Rivista)

Insieme di parole chiave di

• Keywords of "Small molecules interacting with alpha-synuclein: antiaggregating and cytoprotective properties" (Insieme di parole chiave)