Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (Articolo in rivista)

Type
Label
  • Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Alternative label
  • Enrica Calce, Luca Monfregola, Annamaria Sandomenico, Michele Saviano, Stefania De Luca (2013)
    Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach
    in European journal of medicinal chemistry (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Enrica Calce, Luca Monfregola, Annamaria Sandomenico, Michele Saviano, Stefania De Luca (literal)
Pagina inizio
  • 116 (literal)
Pagina fine
  • 121 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 61 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Biostrutture e Bioimmagini (IBB) (literal)
Titolo
  • Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (literal)
Abstract
  • Fluorescence titrations allowed us to study the interaction process between Herceptin (Fab)-derived peptides and a synthetic peptide mimicking a subdomain IV of the receptor HER2 (HER2-DIVMP). For some of the investigated peptide/HER2-DIVMP complexes a nanomolar dissociation constant was found. The performed interaction studies were completely immune from interferences of other receptor domains not covered by the design, thus decreasing the possibilities of selecting potential ligands able to bind other subtypes of HER2 receptor family. Our results demonstrate that the adopted receptor fragment approach represents an efficient methodology for selecting new molecules as lead structures specific for the receptor target. For these reasons the optimized compounds could be employed as delivery agents for the receptor-mediated anticancer therapy (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it