http://www.cnr.it/ontology/cnr/individuo/prodotto/ID217446
Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (Articolo in rivista)
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- Label
- Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Alternative label
Enrica Calce, Luca Monfregola, Annamaria Sandomenico, Michele Saviano, Stefania De Luca (2013)
Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach
in European journal of medicinal chemistry (Online)
(literal)
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- Enrica Calce, Luca Monfregola, Annamaria Sandomenico, Michele Saviano, Stefania De Luca (literal)
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- Istituto di Biostrutture e Bioimmagini (IBB) (literal)
- Titolo
- Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (literal)
- Abstract
- Fluorescence titrations allowed us to study the interaction process between Herceptin (Fab)-derived
peptides and a synthetic peptide mimicking a subdomain IV of the receptor HER2 (HER2-DIVMP). For
some of the investigated peptide/HER2-DIVMP complexes a nanomolar dissociation constant was found.
The performed interaction studies were completely immune from interferences of other receptor
domains not covered by the design, thus decreasing the possibilities of selecting potential ligands able to
bind other subtypes of HER2 receptor family. Our results demonstrate that the adopted receptor fragment
approach represents an efficient methodology for selecting new molecules as lead structures
specific for the receptor target. For these reasons the optimized compounds could be employed as
delivery agents for the receptor-mediated anticancer therapy (literal)
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