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Iron oxide-gold core-shell nanoparticles as multimodal imaging contrast agent (Articolo in rivista)

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Iron oxide-gold core-shell nanoparticles as multimodal imaging contrast agent (Articolo in rivista) (literal)

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Luca Menichetti, Leonardo Manzoni, Luigi Paduano, A. Flori, Claudia Kusmic, Daniele De Marchi, Sergio Casciaro, Francesco Conversano, Massimo Lombardi, Vincenzo Positano, Daniela Arosio (2013)
Iron oxide-gold core-shell nanoparticles as multimodal imaging contrast agent
in IEEE sensors journal
(literal)

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Luca Menichetti, Leonardo Manzoni, Luigi Paduano, A. Flori, Claudia Kusmic, Daniele De Marchi, Sergio Casciaro, Francesco Conversano, Massimo Lombardi, Vincenzo Positano, Daniela Arosio (literal)

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Luca Menichetti, Institute of Clinical Physiology, CNR, Pisa I-56124, Italy and CNR-Regione Toscana Fondazione G. Monasterio, Pisa 56124, Italy Claudia Kusmic, Institute of Clinical Physiology, CNR, Pisa I-56124, Italy Daniele De Marchi, Massimo Lombardi, Vincenzo Positano, CNR-Regione Toscana Fondazione G. Monasterio, Pisa 56124, Italy Sergio Casciaro, Francesco Conversano, Institute of Clinical Physiology, CNR, Pisa I-56124, Italy and Institute of Clinical Physiology, CNR, Lecce 73100, Italy . Luigi Paduano, Chemistry Department, University of Naples Federico II, Naples 80138, Italy. A. Flori, Istituto di Scienze della Vita, Scuola Superiore sant'Anna, Pisa 56127, Italy. Leonardo Manzoni, Daniela Arosio, Institute of Sciences and Molecular Technology, CNR, Milan 20133, Italy. (literal)

Titolo

Iron oxide-gold core-shell nanoparticles as multimodal imaging contrast agent (literal)

Abstract

Nanoparticles (NPs) are emerging as a potential medical tool for novel diagnostic, drug delivery, and therapeutic approaches. Among them, a spherical NP with a core-shell structure is a way to combine multiple functionalities on the nanoscale. In this paper, we describe the preparation characterization and applications of core-shell iron oxide-gold nanoparticles (Fe3O 4@Au NPs). A comprehensive set of experiments, including transmission electron microscopy, dynamic light scattering, small angle neutron scattering, and ultraviolet visible spectroscopy is applied to characterize their chemical, physical, and optical properties. We also study their applicability as contrast agents for magnetic resonance imaging (MRI): the measurement of longitudinal and transverse relaxation times of Fe3O4@Au NPs in vitro and in vivo allowed the assessment of longitudinal (R1) and transverse (R2) relaxivities at 1.5 and 3 T. Finally, a procedure for functionalizing NPs with integrin targeting cyclic Arginine-Glycine-Aspartate peptidomimetic is reported, leading to the development of nanoscale probes for ?v?3 integrin, particularly attractive in terms of resolution and 3-D imaging capabilities. The resulting multifunctional nanoprobes offer suitable blood-circulation time and contrast for microimaging as well as for gradient-echo MRI, and could enable new imaging magnetoplasmonic applications. (literal)

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