Selection of HTLV-I positive clones is prevented by prostaglandin A in infected cord blood cultures. (Articolo in rivista)

Type
Label
  • Selection of HTLV-I positive clones is prevented by prostaglandin A in infected cord blood cultures. (Articolo in rivista) (literal)
Anno
  • 1990-01-01T00:00:00+01:00 (literal)
Alternative label
  • 1)D'Onofrio C, 2)Alvino E, 1)Garaci E, 1,2)Bonmassar E, 1,2)Santoro MG. (1990)
    Selection of HTLV-I positive clones is prevented by prostaglandin A in infected cord blood cultures.
    in British Journal of Cancer
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • 1)D'Onofrio C, 2)Alvino E, 1)Garaci E, 1,2)Bonmassar E, 1,2)Santoro MG. (literal)
Pagina inizio
  • 207 (literal)
Pagina fine
  • 14 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 61 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • PubMed (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Department of Experimental Medicine and Biochemical Science,University of Tor Vergata, Rome, Italy 2 Institute of Experimental Medicine, CNR, Rome, Italy (literal)
Titolo
  • Selection of HTLV-I positive clones is prevented by prostaglandin A in infected cord blood cultures. (literal)
Abstract
  • Type A prostaglandins (PGA1 and 16,16-dimethyl-PGA2-methyl ester) were found to block the proliferation of HTLV-I infected cord blood lymphocytes (CBL) in vitro, thus preventing the clonal immortalisation that is considered as a predisposing condition to HTLV-I positive leukaemia. PGA1 and di-M-PGA2 did not affect the long-term survival of normal non-infected CBL, whereas they suppressed the proliferation of an established cord-blood derived HTLV-I positive cell line, MT-2. As shown by the number of HTLV-I infected p19+ cells, the block of the selection of immortalised, infected clones by PGAs did not appear to be due to an inhibition of early stages of HTLV-I infection. The possibility that the effect of PGAs could be mediated by an action on the immune response was also examined. PGAs regulated the cell-mediated cytotoxic function of CBL to a different extent when normal non-infected or HTLV-I exposed CBL were compared. In fact, PGAs down-regulated the natural killing and macrophage/lymphocyte cytotoxic response of normal CBL, whereas they did not modify the already depressed immune response of CBL challenged with HTLV-I. These results suggest that the protective effect of PGAs against HTLV-I infection in vitro is mostly related to the direct suppression of the clonal expansion of virus-infected cells, rather than to the anti-viral activity or modulation of the cell-mediated immunity. (literal)
Autore CNR

Incoming links:


Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it