http://www.cnr.it/ontology/cnr/individuo/prodotto/ID215887
Selection of HTLV-I positive clones is prevented by prostaglandin A in infected cord blood cultures. (Articolo in rivista)
- Type
- Label
- Selection of HTLV-I positive clones is prevented by prostaglandin A in infected cord blood cultures. (Articolo in rivista) (literal)
- Anno
- 1990-01-01T00:00:00+01:00 (literal)
- Alternative label
1)D'Onofrio C, 2)Alvino E, 1)Garaci E, 1,2)Bonmassar E, 1,2)Santoro MG. (1990)
Selection of HTLV-I positive clones is prevented by prostaglandin A in infected cord blood cultures.
in British Journal of Cancer
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- 1)D'Onofrio C, 2)Alvino E, 1)Garaci E, 1,2)Bonmassar E, 1,2)Santoro MG. (literal)
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- 1 Department of Experimental Medicine and Biochemical Science,University of Tor Vergata, Rome, Italy
2 Institute of Experimental Medicine, CNR, Rome, Italy (literal)
- Titolo
- Selection of HTLV-I positive clones is prevented by prostaglandin A in infected cord blood cultures. (literal)
- Abstract
- Type A prostaglandins (PGA1 and 16,16-dimethyl-PGA2-methyl ester) were found to block the proliferation of HTLV-I infected cord blood lymphocytes (CBL) in vitro, thus preventing the clonal immortalisation that is considered as a predisposing condition to HTLV-I positive leukaemia. PGA1 and di-M-PGA2 did not affect the long-term survival of normal non-infected CBL, whereas they suppressed the proliferation of an established cord-blood derived HTLV-I positive cell line, MT-2. As shown by the number of HTLV-I infected p19+ cells, the block of the selection of immortalised, infected clones by PGAs did not appear to be due to an inhibition of early stages of HTLV-I infection. The possibility that the effect of PGAs could be mediated by an action on the immune response was also examined. PGAs regulated the cell-mediated cytotoxic function of CBL to a different extent when normal non-infected or HTLV-I exposed CBL were compared. In fact, PGAs down-regulated the natural killing and macrophage/lymphocyte cytotoxic response of normal CBL, whereas they did not modify the already depressed immune response of CBL challenged with HTLV-I. These results suggest that the protective effect of PGAs against HTLV-I infection in vitro is mostly related to the direct suppression of the clonal expansion of virus-infected cells, rather than to the anti-viral activity or modulation of the cell-mediated immunity. (literal)
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