Comparative Efficacy and Safety of 3-Day Azithromycin and10-Day Penicillin V Treatment of Group A Beta-Hemolytic Streptococcal Pharyngitis in Children (Articolo in rivista)

Type
Label
  • Comparative Efficacy and Safety of 3-Day Azithromycin and10-Day Penicillin V Treatment of Group A Beta-Hemolytic Streptococcal Pharyngitis in Children (Articolo in rivista) (literal)
Anno
  • 1996-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1097/00006454-199705000-00033 (literal)
Alternative label
  • 1)LUCIA PACIFICO;2) FRANCA SCOPETTI;1)ALESSANDRO RANUCCI;2) MARCO PATARACCHIA;1) FERDINANDO SAVIGNONI;3) CLAUDIO CHIESA (1996)
    Comparative Efficacy and Safety of 3-Day Azithromycin and10-Day Penicillin V Treatment of Group A Beta-Hemolytic Streptococcal Pharyngitis in Children
    in Antimicrobial agents and chemotherapy (Print); ASM, American society for microbiology, Washington, DC (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • 1)LUCIA PACIFICO;2) FRANCA SCOPETTI;1)ALESSANDRO RANUCCI;2) MARCO PATARACCHIA;1) FERDINANDO SAVIGNONI;3) CLAUDIO CHIESA (literal)
Pagina inizio
  • 1005 (literal)
Pagina fine
  • 1008 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 40 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 4 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
  • ubme (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1)Institute of Pediatrics, Sapienza University of Rome; 2)National Health Institute,Rome; 3)Institute of Experimental Medicine,National Research Council,Rome,Italy. (literal)
Titolo
  • Comparative Efficacy and Safety of 3-Day Azithromycin and10-Day Penicillin V Treatment of Group A Beta-Hemolytic Streptococcal Pharyngitis in Children (literal)
Abstract
  • The efficacy and safety of a 3-day course of azithromycin oral suspension (10 mg/kg of body weight once daily) were compared with those of penicillin V (50,000 U/kg/day in two divided doses) in children aged 3 to 12 years for the treatment of symptomatic pharyngitis caused by the group A beta-hemolytic streptococcus (GABHS). For the 154 evaluable patients, the original infecting strain of GABHS was eliminated at the end of follow-up (34 to 36 days after treatment started) from 67 (85.8%) of 78 penicillin-treated patients and 41 (53.9%) of 76 azithromycin-treated patients (P < 0.0001). Overall clinical success was achieved in 71 (91.0%) of 78 penicillin V-treated patients and 57 (75.0%) of 76 azithromycin-treated patients (P < 0.05). Potential drug-related adverse events were reported for 5.5 and 8.6% of the penicillin V- and azithromycin-treated patients, respectively (P = 0.6). In the present study, a once-daily (10 mg/kg), 3-day oral regimen of azithromycin was as safe as a 10-day course of penicillin but did not represent an effective alternative to penicillin for the treatment of GABHS pharyngitis, even for those children with azithromycin-susceptible strains. (literal)
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